Novel Treatments for Chronic Erythema Multiforme Inform Translational Science and Disease Pathogenesis

Abstract

Methods for the Watch the Spot Trial. a pragmatic trial of more-versus less-intensive strategies for active surveillance of small pulmonary nodules. Ann

Multiple large annular and semi‐annular erythema in a young woman

“…Symptomatic treatment may be sufficient for mild EM, antiviral therapy, systemic corticosteroids, or other immunomodulatory therapies like azathioprine, mycophenolate mofetil, dapsone, thalidomide, and Janus kinase inhibitors can be considered in severe or recurrent cases. 1,4 In this patient, no mucocutaneous lesions suspicious for HSV infection were found. We used polymerase chain reaction to detect HSV DNA in lesional skin biopsy to examine subclinical HSV infection, but the result was negative.…”

“…The management of EM is based on the disease severity, especially the mucosal involvements, the clinical course, and the possible inciting factors. Symptomatic treatment may be sufficient for mild EM, antiviral therapy, systemic corticosteroids, or other immunomodulatory therapies like azathioprine, mycophenolate mofetil, dapsone, thalidomide, and Janus kinase inhibitors can be considered in severe or recurrent cases 1,4 …”