2015
DOI: 10.1007/s40473-015-0032-7
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Novel Treatments of Psychosis

Abstract: Since the advent of chlorpromazine in the 1950s, D 2 receptor antagonist activity has been synonymous with antipsychotic medications. This single mechanism of action may explain the similarities in efficacy among approved antipsychotics. Additionally, extrapyramidal and metabolic side effects of antipsychotics present a significant burden to patient quality of life. Development of the next generation of antipsychotics has focused on novel mechanisms of action including drugs that act through the N-methyl-D-asp… Show more

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