Novel Ultrasound Methods to Investigate Carotid Artery Plaque Vulnerability

Johri, Amer M.; Herr, Julia E.; Li, Terry Y; Yau, Olivia; Nambi, Vijay

doi:10.1016/j.echo.2016.11.003

Cited by 34 publications

(18 citation statements)

References 70 publications

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“…(A): Grayscale median (GSM) analysis of carotid plaque is conducted by creating a region of interest outlining the plaque, normalizing the plaque so that the lumen is 0 and the adventitia is 190, and obtaining the GSM from the histogram of gray value distribution in the normalized plaque. Adapted from Johri et al 69 with permission. (B): Pixel distribution analysis (PDA) showing the color-mapped grayscale ranges representative of different tissue types.…”

Section: Three-dimensional Plaque Quantificationmentioning

confidence: 99%

Recommendations for the Assessment of Carotid Arterial Plaque by Ultrasound for the Characterization of Atherosclerosis and Evaluation of Cardiovascular Risk: From the American Society of Echocardiography

Johri

Nambi

Naqvi

et al. 2020

Journal of the American Society of Echocardiography

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207

140

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Atherosclerotic plaque detection by carotid ultrasound provides cardiovascular disease risk stratification. The advantages and disadvantages of two-dimensional (2D) and three-dimensional (3D) ultrasound methods for carotid arterial plaque quantification are reviewed. Advanced and emerging methods of carotid arterial plaque activity and composition analysis by ultrasound are considered. Recommendations for the standardization of focused 2D and 3D carotid arterial plaque ultrasound image acquisition and measurement for the purpose of cardiovascular disease stratification are formulated. Potential clinical application towards cardiovascular risk stratification of recommended focused carotid arterial plaque quantification approaches are summarized. (J

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Section: Three-dimensional Plaque Quantificationmentioning

confidence: 99%

Recommendations for the Assessment of Carotid Arterial Plaque by Ultrasound for the Characterization of Atherosclerosis and Evaluation of Cardiovascular Risk: From the American Society of Echocardiography

Johri

Nambi

Naqvi

et al. 2020

Journal of the American Society of Echocardiography

Self Cite

207

140

View full text Add to dashboard Cite

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“…Advanced neurosonology, including 3D ultrasound and contrast-enhanced ultrasound imaging may clarify in detail plaque shape and size, but also the degree of intra-plaque neovascularization and hemorrhage. 167,168 Morphology and neovascularization may also be evaluated by high-resolution contrast-enhanced MRI with higher field strength (Tesla). 169 Microemboli detection has also been shown as an effective and non-invasive approach to evaluate on-going embolization.…”

Section: The Role Of Rare Etiologiesmentioning

confidence: 99%

Short-Term Outcome and In-Hospital Complications After Acute Cerebral Infarcts in Multiple Arterial Territories

Novotný

Khanevski

Bjerkreim

et al. 2019

Stroke

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Background and Purpose— Patients with acute cerebral infarcts in multiple arterial territories (MACI) represent a substantial portion of the stroke population. There are no data on short-term outcome and in-hospital complications in patients with MACI. We compared patients with MACI with patients having acute cerebral infarct(s) in a single arterial territory. Methods— We analyzed 3343 patients with diffusion-weighted imaging-confirmed acute cerebral infarcts. MACI was defined as at least 2 acute cerebral ischemic lesions in at least 2 arterial cerebral territories. Patients with MACI were compared with patients with acute cerebral infarct(s) in a single arterial territory for relevant in-hospital complications and short-term outcome, namely National Institutes of Health Stroke Scale and modified Rankin Scale at day 7 after admission or at discharge when earlier. Results— A total of 311 patients (9.3%) met the definition of MACI. Both median National Institutes of Health Stroke Scale (2 [1–7] versus 1 [0–4]) and modified Rankin Scale (3 [1–4] versus 2 [1–3]) were higher in patients with MACI. MACI was independently associated with higher National Institutes of Health Stroke Scale and modified Rankin Scale. Deep venous thrombosis, myocardial infarction, and any complications were more frequent in patients with MACI. Conclusions— In-hospital complications were more frequent in patients with MACI, which may adversely affect short-term clinical and functional outcome. Closer follow-up of patients with MACI during hospitalization may prevent such events and negative progression.

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“…Several recent methods and techniques are now available for the in vivo imaging and assessment of the extent of vasa vasorum and plaque neovascularization; some of them are based on magnetic resonance imaging, computed tomography, positron emission tomography ( 9 - 11 ), but contrast-enhanced ultrasound (CEUS) imaging is undoubtedly the most widely used technique ( 12 , 13 ) apart from intravascular ultrasound ( 14 - 16 ). Methods using CEUS are based on the use of contrast medium (microbubbles) that can cause changes in the echolucency and echogenicity of arterial wall and plaque regions of interest (ROI) yielding qualitative, semiquantitative, and quantitative information regarding the presence and the extent of vasa vasorum and neovascularization.…”

Section: Introductionmentioning

confidence: 99%

Computational imaging of aortic vasa vasorum and neovascularization in rabbits using contrast enhanced intravascular ultrasound: association with histology analysis

Vavuranakis¹

2018

Anatol J Cardiol

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Objective:Neoangiogenesis is pathophysiologically related to atherosclerotic plaque growth and vulnerability. We examined the in vivo performance of a computational method using contrast-enhanced intravascular ultrasound (CE-IVUS) to detect and quantify aortic wall neovascularization in rabbits. We also compared these findings with histological data.Methods:Nine rabbits were fed with a hyperlipidemic diet. IVUS image sequences were continuously recorded before and after the injection of a contrast agent. Mean enhancement of intensity of a region of interest (MEIR) was calculated using differential imaging algorithm. The percent difference of MEIR before and after the injection of microbubbles (d_MEIR) was used as an index of the density of plaque or/and adventitial neovascularization. Aortic segments were excised for histological analysis.Results:CE-IVUS and histological analysis were performed in 11 arterial segments. MEIR was significantly increased (~20%) after microbubble injection (from 8.1±0.9 to 9.7±1.8, p=0.016). Segments with increased VV/neovessels in the tunica adventitia (histological scores 2 and 3) had significantly higher d_MEIR compared with segments with low presence of VV/neovessels (score 1); 40.5±22.9 vs. 8±14.6, p=0.024, respectively.Conclusion:It is possible to detect VV or neovessels in vivo using computational analysis of CE-IVUS images, which is in agreement with histological data. These findings may have critical implications on vulnerable plaque assessment and risk stratification.

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Novel Ultrasound Methods to Investigate Carotid Artery Plaque Vulnerability

Cited by 34 publications

References 70 publications

Recommendations for the Assessment of Carotid Arterial Plaque by Ultrasound for the Characterization of Atherosclerosis and Evaluation of Cardiovascular Risk: From the American Society of Echocardiography

Recommendations for the Assessment of Carotid Arterial Plaque by Ultrasound for the Characterization of Atherosclerosis and Evaluation of Cardiovascular Risk: From the American Society of Echocardiography

Short-Term Outcome and In-Hospital Complications After Acute Cerebral Infarcts in Multiple Arterial Territories

Computational imaging of aortic vasa vasorum and neovascularization in rabbits using contrast enhanced intravascular ultrasound: association with histology analysis

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