Novel Uracil Derivatives: Newly Synthesized Centrally Acting Agents.

Infrared multiple photon dissociation action spectroscopy of protonated uracil and thiouracils: Effects of thioketo-substitution on gas-phase conformation

“…The replacement of uracil by thiouracils in m-RNA can lead to misrecognition and results in mutation [37]. Interestingly, the substitution of oxygen by sulfur and further methyl-substitution of uracil results in modified nucleobases that have found use in many pharmacological applications [34,[38][39][40][41][42][43][44][45][46][47][48][49][50][51]. 2-Thiouracil and 4-thiouracil are well known for their use in antithyroid, anticancer [34,38,39], and heart disease treatments [40,41].…”

Optimizing the reversibility of hydrazone formation for dynamic combinatorial chemistry

“…Others can be synthesised by acylation of hydrazine precursors (1, 2), 11 by aromatic nucleophilic substitution (5), 12 or by amination of endocyclic nitrogens (6). 13 The effect of the electron withdrawing substituents is illustrated by the low basicity of most of these amino groups (Table 1).…”

Hypervalent Iodine in Synthesis 91: A Mild and Efficient Method for the Halogenation of 6-Methyluracil Derivatives

“…1 Recently 5-halogenouracil derivatives have been used as sedatives. 2 Some of these 5-halogenouracil derivatives had been shown to be good starting materals. 3 The methods reported for the preparation of 5-halogenouracil derivatives.…”