Novel Use of Erbium

Lapidoth, Moshe; Odo, Marina Emiko Yagima; Odo, Lilian Mayumi

doi:10.1097/00042728-200808000-00011

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…The depth of individual microchannels varies from 25 to 1,000 μm, corresponding to the level of epidermis, or even dermis. Therefore, microchannels of FLA represent ideal pathways allowing skin permeation of macromolecular compounds ( Fisher and Geronemus, 2005 ; Lapidoth et al, 2008 ). In addition, the surrounding CZs have been shown to be able to further promote topical uptake of drugs ( Haak et al, 2017 ).…”

Section: Physical Transdermal Drug Delivery Systemsmentioning

confidence: 99%

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Qin

Dai

et al. 2022

Front. Bioeng. Biotechnol.

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Psoriasis is a chronic, immune-mediated skin disorder involving hyperproliferation of the keratinocytes in the epidermis. As complex as its pathophysiology, the optimal treatment for psoriasis remains unsatisfactorily addressed. Though systemic administration of biological agents has made an impressive stride in moderate-to-severe psoriasis, a considerable portion of psoriatic conditions were left unresolved, mainly due to adverse effects from systemic drug administration or insufficient drug delivery across a highly packed stratum corneum via topical therapies. Along with the advances in nanotechnologies, the incorporation of nanomaterials as topical drug carriers opens an obvious prospect for the development of antipsoriatic topicals. Hence, this review aims to distinguish the benefits and weaknesses of individual nanostructures when applied as topical antipsoriatics in preclinical psoriatic models. In view of specific features of each nanostructure, we propose that a proper combination of distinctive nanomaterials according to the physicochemical properties of loaded drugs and clinical features of psoriatic patients is becoming a promising option that potentially drives the translation of nanomaterials from bench to bedside with improved transdermal drug delivery and consequently therapeutic effects.

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Section: Physical Transdermal Drug Delivery Systemsmentioning

confidence: 99%

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Qin

Dai

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…There is a stimulus of collagen production, which results in more youthful skin without the inconvenience of a long downtime. Melanin is also eliminated through the microscopic epidermal necrotic debris, promoting gradual lightening of the skin 1 …”

mentioning

confidence: 99%