The design of a mixed-mode proportional-integral-derivative (PID) controller circuit using current-feedback operational amplifiers (CFOAs) as active components is proposed. With the same circuit topology, the proposed configuration of three CFOAs, four resistors, and two capacitors is capable of performing the PID controller in each of the following four modes: voltage mode, trans-admittance mode, current mode, and trans-impedance mode. Numerous mathematical analyses are conducted to determine the controller’s performance under both ideal and non-ideal conditions. Additionally, the mixed-mode second-order lowpass filter is suggested and also used to examine the workability of the proposed mixed-mode PID controller in a feedback control structure. The proposed PID controller is implemented with the commercially available IC-type CFOA AD844, and the simulation results are presented to illustrate the functionality of the controller and its closed-loop control system. According to the findings, the total power consumption of the proposed PID controller is 0.348 W, with symmetrical supply voltages of ±9 V. It also has a temperature variation of less than 0.2% over the AD844’s usable range. Monte Carlo statistical analysis results revealed that the gain responses of the controller exhibited a deviation of no more than 7.72% from the theoretical value. The controlled filter in a closed-loop control system has a 43% faster rise time and peak time than the uncontrolled filter in all four modes of operation. It also has a steady-state error less than 0.2 mV for voltage responses and 0.72 µA for current responses.