2012
DOI: 10.1152/japplphysiol.00818.2011
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Novel whole body plethysmography system for the continuous characterization of sleep and breathing in a mouse

Abstract: Sleep is associated with marked alterations in ventilatory control that lead to perturbations in respiratory timing, breathing pattern, ventilation, pharyngeal collapsibility, and sleep-related breathing disorders (SRBD). Mouse models offer powerful insight into the pathogenesis of SRBD; however, methods for obtaining the full complement of continuous, high-fidelity respiratory, electroencephalographic (EEG), and electromyographic (EMG) signals in unrestrained mice during sleep and wake have not been developed… Show more

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Cited by 56 publications
(66 citation statements)
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References 46 publications
(77 reference statements)
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“…Historically, apneas in rodents have been described as exclusively central events and the upper airway anatomy of mice and rats is more stable than the upper airway of humans. Although the recent work by Hernandez et al (2012) suggests that obese mice can demonstrate flow limitation of the upper airway, it is still unclear whether clinically relevant obstructive apneas occur in sleeping rodents. A potential approach to addressing the question of whether or not rodents have obstructive events would be to utilize diaphragm and/or intercostal EMGs to measure respiratory effort simultaneously with airflow measurements.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Historically, apneas in rodents have been described as exclusively central events and the upper airway anatomy of mice and rats is more stable than the upper airway of humans. Although the recent work by Hernandez et al (2012) suggests that obese mice can demonstrate flow limitation of the upper airway, it is still unclear whether clinically relevant obstructive apneas occur in sleeping rodents. A potential approach to addressing the question of whether or not rodents have obstructive events would be to utilize diaphragm and/or intercostal EMGs to measure respiratory effort simultaneously with airflow measurements.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, leptin-deficient ob/ob mice have defects in upper airway neuromechanical control which is reversed with leptin administration (Polotsky et al, 2012), which suggests that leptin protects against upper airway obstruction in obese mice, and that mice deficient in leptin may be vulnerable to the development of obstructive apnea. In a follow-up study, Hernandez et al (2012) used plethysmography and polysomnography to obtain short-term characterization of sleep and breathing in the New Zealand obese mouse. With adaptation of an infant blood pressure cuff, respiratory movement was estimated and compared to signals of airflow to determine whether reduced upper airway flow occurred in the presence or absence of respiratory movement.…”
Section: Rodents As Natural Models Of Sleep Apneamentioning
confidence: 99%
“…The actual demonstration of OSA in rodents was made possible by the development of a plethysmography system by Hernandez and colleagues (13) in 2012. Their system built upon existing technology to measure respiration in unrestrained mice, but with modifications, including continuous measurements of breathing, tidal volume, and respiratory effort.…”
Section: Animals With Spontaneous Sleep Apneamentioning
confidence: 99%
“…The EMG GG was rectified, and a 100 ms time constant was applied to compute the moving average (LabChart Pro 7). Respiratory effort was monitored with a sensing bladder wrapped around the mouse as previously described 35 . DREADD infected mice (n = 13) were treated with clozapine-N-oxide (CNO, 1 mg/kg in saline i.p.)…”
Section: Electromyography Of the Genioglossus Muscle (Emg Ggmentioning
confidence: 99%