Novel zinc complexes of a non-steroidal anti-inflammatory drug, niflumic acid: Structural characterization, human-DNA and albumin binding properties

Smolková, Romana; Zeleňák, Vladimı́r; Kuchár, Juraj; Rabajdová, Miroslava; Ferenčáková, Michaela; Mareková, Mária

doi:10.1016/j.ejmech.2017.05.009

Cited by 22 publications

(4 citation statements)

References 35 publications

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“…Niflumic acid (nif) is the member of the class of drugs known as NSAIDs and it is used to treat inflammatory rheumatoid diseases, pain and fever. Although the copper(II), cobalt(II), manganese(II), silver(II), and zinc(II) complexes of niflumic acid were reported, in the literature, the number of synthesized complexes with niflumic acid is less than the other NSAIDs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3‐picoline on paraoxanase‐I

Dilek

Çağlar

Çardak

et al. 2019

Archiv der Pharmazie

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Niflumic acid is used to treat inflammatory rheumatoid diseases, pain, and fever. The present study reports the experimental, spectroscopic, thermal, structural analyses, and biological activities of this complex. The nonsteroidal anti-inflammatory drug niflumic acid, 3-picoline, and copper(II) chloride were utilized to synthesize a new complex: [Cu 2 Cl 2 (nif) 2 (3-pic) 4 ]. The crystal structure of [Cu 2 Cl 2 (nif) 2 (3-pic) 4 ] was determined by X-ray crystallography. The complex crystallizes in the triclinic space group P-1 and each Cu(II) center displayed six-coordinated distorted octahedral geometry. Two Cu(II) centers are connected by a chloro-bridge to form the binuclear metal core. Finally, the in vitro effects of the synthesized new complex and free niflumic acid were evaluated on the human serum paraoxonase 1 enzyme. At low doses, both the new complex and free niflumic acid showed very good inhibition activity with different inhibition mechanisms. In addition, the results showed that the new complex has more inhibition activity than free niflumic acid.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3‐picoline on paraoxanase‐I

Dilek

Çağlar

Çardak

et al. 2019

Archiv der Pharmazie

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“…Quenching is typically categorized into two types: dynamic quenching and static quenching, which differ in their sensitivity to temperature and viscosity [20]. To qualitatively explore the quenching mechanism of HSA by isoflucypram, the fluorescence data were analyzed in depth using the Stern-Volmer equation, and the following relationship was found to exist between F 0 /F and [Q] [21,22]:…”

Section: Fluorescence Quenching Mechanismmentioning

confidence: 99%

Probing the Interaction between Isoflucypram Fungicides and Human Serum Albumin: Multiple Spectroscopic and Molecular Modeling Investigations

Li,

Yan,

Yang

et al. 2023

IJMS

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To better understand the potential toxicity risks of isoflucypram in humans, The interaction between isoflucypram and HSA (human serum albumin) was studied through molecular docking, molecular dynamics simulations, ultraviolet–visible absorption, fluorescence, synchronous fluorescence, three-dimensional fluorescence, Fourier transform infrared spectroscopies, and circular dichroism spectroscopies. The interaction details were studied using the molecular docking method and molecular dynamics simulation method. The results revealed that the effect of isoflucypram on human serum albumin was mixed (static and dynamic) quenching. Additionally, we were able to obtain important information on the number of binding sites, binding constants, and binding distance. The interaction between isoflucypram and human serum albumin occurred mainly through hydrogen bonds and van der Waals forces. Spectroscopic results showed that isoflucypram caused conformational changes in HSA (human serum albumin), in which the α-helix was transformed into a β-turn, β-sheet, and random coil, causing the HSA structure to loosen. By providing new insights into the mechanism of binding between isoflucypram and human serum albumin, our study has important implications for assessing the potential toxicity risks associated with isoflucypram exposure.

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“…Derivatives of fenamic acid, known as fenamates and salicylates, belong to the most common NSAIDs used for synthesizing complexes. Despite the fact that numerous Zn( ii ), 7–10 Cu( ii ), 11–15 Co( ii ) 16–18 and Mn( ii ) 19–22 complexes have been studied in recent years, the relationship between their structure and biological activity remains unclear. However, some recent studies have revealed that various fenamato ligands in structurally similar complexes can exhibit different biological activity, thus emphasizing the role of additional substituents such as methyl (mefenamic acid), trifluoromethyl (flufenamic acid) or chloro groups (tolfenamic acid) in the fenamato ligands.…”

Section: Introductionmentioning

confidence: 99%

Investigation of novel Mn(ii) fenamato complexes with neocuproine and their effects on endometrial cell lines

et al. 2023

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Novel zinc complexes of a non-steroidal anti-inflammatory drug, niflumic acid: Structural characterization, human-DNA and albumin binding properties

Cited by 22 publications

References 35 publications

Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3‐picoline on paraoxanase‐I

Synthesis, characterization, and in vitro effect of the Cu(II) complex with niflumic acid and 3‐picoline on paraoxanase‐I

Probing the Interaction between Isoflucypram Fungicides and Human Serum Albumin: Multiple Spectroscopic and Molecular Modeling Investigations

Investigation of novel Mn(ii) fenamato complexes with neocuproine and their effects on endometrial cell lines

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