Novel Zn(II)-complex with hybrid chalcone-thiosemicarbazone ligand: Synthesis, characterization, and inhibitory effect on HTLV-1-infected MT-2 leukemia cells

Campos, Maria Clara; Barbosa, Igor Resendes; Guedes, Guilherme P.; Echevarrı́a, Aurea; Echevarria-Lima, Juliana; Chaves, Otávio Augusto

doi:10.1016/j.jinorgbio.2023.112239

Journal of Inorganic Biochemistry

2023

DOI: 10.1016/j.jinorgbio.2023.112239

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Novel Zn(II)-complex with hybrid chalcone-thiosemicarbazone ligand: Synthesis, characterization, and inhibitory effect on HTLV-1-infected MT-2 leukemia cells

Maria Clara Campos

Igor Resendes Barbosa

Guilherme P. Guedes

et al.

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Cited by 4 publications

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Application of Chalcone in the Structural Modification of Natural Products: An Overview

Quan,

Liu,

Wang

et al. 2024

Chemistry & Biodiversity

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Natural products frequently display a range of biological activities, yet many exhibit only moderate efficacy during initial evaluations. Often, these natural substances necessitate structural alterations to yield promising lead compounds. Chalcones, characterized by their β‐unsaturated carbonyl aromatic ketone structure, are prevalent in plant life and serve as fundamental scaffolds for the biosynthetic precursors of flavonoids and isoflavones. Due to their straightforward synthesis and extensive spectrum of biological effects, chalcones have found extensive application in medicinal chemistry. Chalcone analogs have demonstrated significant potential for drug discovery and development, as structural modifications can both amplify pharmacological efficacy and effectively mitigate toxic side effects. This paper endeavors to delve into the applications of chalcones in the structural modification of natural products, providing a theoretical foundation for future endeavors in derivatization and drug development. The full paper is organized into categories based on the biological activities of the derivatives, including anti‐dyslipidemic, antibacterial, antimalarial, anti‐inflammatory, anticancer, anti‐Alzheimer, and α‐glucosidase inhibitory activities.

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Application of Chalcone in the Structural Modification of Natural Products: An Overview

Quan,

Liu,

Wang

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

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A review on zinc, cadmium, and mercury complexes with anticancer activity

Saeedian Moghadam,

Emamgholipour,

Foroumadi

et al. 2024

Inorganic Chemistry Communications

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Dinuclear copper(II) complexes with a bridging bis(chalcone) ligand reveal considerable in vitro cytotoxicity on human cancer cells and enhanced selectivity

Trávníček,

Vančo,

Belza

et al. 2024

Journal of Inorganic Biochemistry

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Novel Zn(II)-complex with hybrid chalcone-thiosemicarbazone ligand: Synthesis, characterization, and inhibitory effect on HTLV-1-infected MT-2 leukemia cells

Cited by 4 publications

References 56 publications

Application of Chalcone in the Structural Modification of Natural Products: An Overview

Application of Chalcone in the Structural Modification of Natural Products: An Overview

A review on zinc, cadmium, and mercury complexes with anticancer activity

Dinuclear copper(II) complexes with a bridging bis(chalcone) ligand reveal considerable in vitro cytotoxicity on human cancer cells and enhanced selectivity

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