2010
DOI: 10.1002/iub.288
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Novobiocin decreases SMYD3 expression and inhibits the migration of MDA‐MB‐231 human breast cancer cells

Abstract: SummarySET and MYND domain-containing protein 3 (SMYD3) is a histone methyltransferase that plays an important role in transcriptional regulation in human carcinogenesis, and heat-shock protein HSP90A has been shown to increase the activity of SMYD3. We previously reported that overexpression of SMYD3 stimulated the migration of cells. In this study, we further found that novobiocin, a HSP90 inhibitor, could decrease the expression of SMYD3 and dose dependently inhibit the proliferation and migration of MDA-MB… Show more

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Cited by 37 publications
(26 citation statements)
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“…1 and Supplementary Table S4), were verteporfin (33), resveratrol (34), and novobiocin (35), all of which have already been shown to inhibit migration and/or the metastatic development of cancer cells (Table 1; refs. [33][34][35]. Upon drug treatment by any of these three drugs (Fig.…”
Section: Prediction Of Novel Drug Compounds For Metastatic Colorectalmentioning
confidence: 99%
“…1 and Supplementary Table S4), were verteporfin (33), resveratrol (34), and novobiocin (35), all of which have already been shown to inhibit migration and/or the metastatic development of cancer cells (Table 1; refs. [33][34][35]. Upon drug treatment by any of these three drugs (Fig.…”
Section: Prediction Of Novel Drug Compounds For Metastatic Colorectalmentioning
confidence: 99%
“…The effect on the cell proliferation was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium (MTT; Sigma, St. Louis, MO, USA) assay was performed as described before (20). Absorbance was directly proportional to the number of survival cells.…”
Section: Microrna-135b Promotes Proliferation Invasion and Migrationmentioning
confidence: 99%
“…Reverse-transcription PCR (RT-PCR) analysis was carried out as described previously (16). Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an internal control to show equal loading of the cDNA samples.…”
Section: Reverse-transcription Polymerase Chain Reaction (Pcr) and Rementioning
confidence: 99%