“…Even with a pessimistic assumption that the efficacy of one dose is lower than two/three doses, adopting a one-dose schedule would free up vaccine doses to allow more rapid scale-up of vaccination, and generate the greatest cost savings and health gains with constrained supply in China. Our results about the one-dose schedule are generally consistent with previous modelling studies, 29 , 30 , 32 , 33 , 34 which suggest promising health benefits (in terms of improving both impact and efficiency) and favourable cost-effectiveness of one-dose strategies. However, few studies have explicitly incorporated supply constraints when comparing the impact of adopting a one-dose schedule with other strategies.…”