NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria

Li, Zhiyu; Liu, Ying; Wang, Yueying; Li, Xiang; Han, Zhuo-na; Hong, Lan; Li, Yingshun; Cui, Xun

doi:10.3892/mmr.2022.12600

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…However, SIRT1 activator resveratrol promoted renal NRK-52E cells to express anti-aging Klotho gene through activating ATF3 [ 41 ]. Similarly, hypoxia-induced ANF secretion in rat atria was decided by SIRT1-reguated ATF3 activation [ 42 ]. Therefore, these reports suggest ATF3 plays a pivotal role in SIRT1-regulated inhibition of non-cancerous cell ferroptosis and promotion of cancer cell ferroptosis.…”

Section: Discussionmentioning

confidence: 99%

SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3

chen,

Wang,

et al. 2024

Redox Biology

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Section: Discussionmentioning

confidence: 99%

SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3

chen,

Wang,

et al. 2024

Redox Biology

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“…Subsequently, the slides were washed with PBS and incubated with 1: 300 dilution of Cy3-conjugated anti-rabbit antibody (Servicebio, GB21303, China) for 50 min at room temperature. Nuclei were stained with DAPI (Servicebio, G1012, China) for 10 min 22 Fluorescence images for peroxisome abundance were obtained using immunofluorescence imaging system (Nikon Eclipse c1, Nikon DS-U3, Japan). The panoramic slice scanner CellQuant and Pat-ternQuant (3DHISTECH, version 2.4.0) were used to the quantitative change of peroxisome abundance.…”

Section: Immunofluorescence Analysismentioning

confidence: 99%

Analysis of kidney proteomes to identify biological pathways associated with vancomycin-induced nephrotoxicity in mice by tandem mass tag-labeled quantitative and parallel reaction monitoring phosphoproteomics

Yang

Yin

et al. 2023

Hum Exp Toxicol

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Vancomycin (VCM)-induced nephrotoxicity impedes its treatment applications. Thus, it is important to clarify the relevant mechanism. This study investigated phosphoprotein changes attributable to the VCM nephrotoxicity mechanisms. Biochemical, pathological and phosphoproteomic analyses based on C57BL/6 mice were performed to explore the mechanisms.VCM-treated mice showed increased levels of blood urea nitrogen and creatinine, and signs of acute tubular necrotic lesions. Phosphoproteomic profiling identified 3025 differentially phosphorylated phosphopeptides between the model and control group. Gene Ontology enrichment analysis demonstrated that Molecular Function “oxidoreductase activity” and Cellular Component “peroxisome” were markedly enriched. KEGG pathway analysis identified an enrichment in peroxisome pathway and PPAR (peroxisome proliferator-activated receptor) signaling pathways. Parallel reaction monitoring analysis revealed a significant downregulation of CAT, SOD-1, AGPS, DHRS4, and EHHADH at phosphorylation level by VCM. Notably, the phosphorylation of ACO, AMACR, and SCPX was downregulated by VCM, which are the fatty acid β-oxidation-related proteins involved in PPAR signaling pathways. The phosphorylated PEX5 involved in peroxisome biogenesis was upregulated by VCM. Collectively, these findings indicated that VCM-induced nephrotoxicity is closely associated with peroxisome pathway and PPAR signaling pathways. The current study provides important insight into the mechanisms of VCM nephrotoxicity and will aid in the development of preventive and therapeutic strategies against this nephropathy.

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NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria

Cited by 2 publications

References 25 publications

SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3

SIRT1 activated by AROS sensitizes glioma cells to ferroptosis via induction of NAD+ depletion-dependent activation of ATF3

Analysis of kidney proteomes to identify biological pathways associated with vancomycin-induced nephrotoxicity in mice by tandem mass tag-labeled quantitative and parallel reaction monitoring phosphoproteomics

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