We adopted a weight of evidence approach to establish a causal analysis of an impaired land ecosystem on a regional scale; namely, Daye, a traditional mining city in China. Working processes, including problem statements, a list of candidate causes, and a conceptual model were developed to represent a causal hypothesis for describing land degradation. Causal criteria were applied to integrate multiple lines of evidence. Then, various pieces of evidence were scored to either strengthen or weaken our causal assumptions. Results showed that habitat alteration, heavy metal accumulation, organic pollutants, water eutrophication, and nutrient runoff were the probable causes of land ecosystem impairment in Daye. Meanwhile, noxious gas, toxicants, altered underground runoff, atmospheric deposition, and acid rain were identified as possible causes. The most unlikely causes were altered hydrology, altered earth surface runoff, and soil erosion. Soil salinization, soluble inorganic salts, biological species invasion, and pathogens were deferred as delayed causes due to lack of adequate information. The causal analysis approach was applied to identify the primary causes of land degradation and implement accurate protective measures in an impaired land ecosystem.