Noxious Stimulation of the Rat Tooth Pulp May Impair Learning and Memory Through the Induction of Hippocampal Apoptosis

Raoof, Maryam; Esmaeili‐Mahani, Saeed; Nourzadeh, Mahdieh; Raoof, Ramin; Abbasnejad, Mehdi; Amirkhosravi, Ladan; Hajializadeh, Zahra; Haghani, Jahangir; Rafie, Forouzan

doi:10.11607/ofph.1452

Cited by 16 publications

(19 citation statements)

References 31 publications

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“…Capsaicin‐induced orofacial pain causes learning and memory impairment in rats (Raoof et al . ,b, Kooshki et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…The effects were inhibited by ibuprofen pre‐treatment (Raoof et al . ,b). Orexin‐A projections and orexin receptors have been found within the areas of the brainstem that are involved in nociception processing (Azhdari‐Zarmehri et al .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, orexinergic fibres and orexin receptors are distributed in some areas of the human brain, including the hippocampus, periaqueductal grey, raphe nuclei, nucleus locus coeruleus and rostral ventromedial medulla (Van Den Pol 1999, Azhdari-Zarmehri et al 2014b, Smutzer & Devassy 2016. Capsaicin-induced orofacial pain causes learning and memory impairment in rats (Raoof et al 2015a,b, Kooshki et al 2016. The present data indicate that intrarostral ventromedial medulla injection of orexin-A attenuates learning and memory impairment in capsaicin-treated rats.…”

Section: Discussionmentioning

confidence: 99%

“…Nociception-related cognitive impairment has been reported in various studies (Yang et al 2014, Raoof et al 2015a,b, Kooshki et al 2016. The hippocampus seems to be anatomically connected to components of the pain neuromatrix such as the periaqueductal grey and rostral ventromedial medulla (Fields et al 2006).…”

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confidence: 99%

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Orexin‐1 receptors in the rostral ventromedial medulla are involved in the modulation of capsaicin evoked pulpal nociception and impairment of learning and memory

et al. 2018

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“…Capsaicin‐induced orofacial pain causes learning and memory impairment in rats (Raoof et al . ,b, Kooshki et al . ).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Orexin‐1 receptors in the rostral ventromedial medulla are involved in the modulation of capsaicin evoked pulpal nociception and impairment of learning and memory

et al. 2018

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“…Although several researches support the association between chronic pain and impaired cognitive function, a small portion of them are focused on orofacial pain. Two studies recently showed that capsaicin-induced pulpal pain is associated with impairment of learning and memory, and neuronal apoptosis in hippocampus of rats ( Raoof et al, 2015a ; Raoof et al, 2015b ).…”

Section: Introductionmentioning

confidence: 99%

Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats

Kooshki

Abbasnejad

Esmaeili‐Mahani

et al. 2017

BCN

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Introduction:Cognitive impairment is commonly associated with pain. The modulatory role of orexin 1 receptor (OX1R) in pain pathways as well as learning and memory processes is reported in several studies. The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain.Methods:Orofacial pain was induced by subcutaneous intra lip injection of capsaicin (100 μg). CA1 administration of orexin A and its selective antagonist (SB-334867-A) were performed 20 minutes prior to capsaicin injection. Learning and spatial memory performances were assessed by Morris Water Maze (MWM) task.Results:Capsaicin treated rats showed impairment in spatial learning and memory. In addition, pretreatment with orexin A (20 and 40 nM/rat) significantly attenuated learning and memory impairment in capsaicin-treated rats. Conversely, blockage of OX1R via SB-334867-A (40 and 80 nM/rat) significantly exaggerated learning and memory loss in capsaicin-treated rats.Conclusion:The obtained results indicated that CA1 OX1R may be involved in modulation of capsaicin –induced spatial learning and memory impairment.

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Methyl jasmonate ameliorates pain‐induced learning and memory impairments through regulating the expression of genes involved in neuroinflammation

Mohammadinia,

Esmaeili‐Mahani,

Abbasnejad

et al. 2024

Brain and Behavior

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ObjectiveOrofacial pain with high prevalence is one of the substantial human health issues. The importance of this matter became more apparent when it was revealed that orofacial pain, directly and indirectly, affects cognition performances. Currently, researchers have focused on investigating pharmaceutics to alleviate pain and ameliorate its subsequent cognitive impairments.DesignIn this study, the rats were first treated with the central administration of methyl jasmonate (MeJA), which is an antioxidant and anti‐inflammatory bio‐compound. After 20 min, orofacial pain was induced in the rats by the injection of capsaicin in their dental pulp. Subsequently, the animals’ pain behaviors were analyzed, and the effects of pain and MeJA treatments on rats learning and memory were evaluated/compared using the Morris water maze (MWM) test. In addition, the expression of tumor necrosis factor‐α (TNF‐α), IL‐1β, BDNF, and COX‐2 genes in the rats’ hippocampus was evaluated using real‐time polymerase chain reaction.ResultsExperiencing orofacial pain resulted in a significant decline in the rats learning and memory. However, the central administration of 20 μg/rat of MeJA effectively mitigated these impairments. In the MWM, the performance of the MeJA‐treated rats showed a two‐ to threefold improvement compared to the nontreated ones. Moreover, in the hippocampus of pain‐induced rats, the expression of pro‐inflammatory factors TNF‐α, IL‐1β, and COX‐2 significantly increased, whereas the BDNF expression decreased. In contrast, MeJA downregulated the pro‐inflammatory factors and upregulated the BDNF by more than 50%.ConclusionsThese findings highlight the notable antinociceptive potential of MeJA and its ability to inhibit pain‐induced learning and memory dysfunction through its anti‐inflammatory effect.

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Noxious Stimulation of the Rat Tooth Pulp May Impair Learning and Memory Through the Induction of Hippocampal Apoptosis

Abstract: Memory and learning impairment induced by noxious stimulation of the rat tooth pulp may be correlated with activation of apoptotic pathways in the hippocampus.

Cited by 16 publications

References 31 publications

Orexin‐1 receptors in the rostral ventromedial medulla are involved in the modulation of capsaicin evoked pulpal nociception and impairment of learning and memory

Orexin‐1 receptors in the rostral ventromedial medulla are involved in the modulation of capsaicin evoked pulpal nociception and impairment of learning and memory

Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats

Methyl jasmonate ameliorates pain‐induced learning and memory impairments through regulating the expression of genes involved in neuroinflammation

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