NR2 antibodies: Risk assessment of transient ischemic attack (TIA)/stroke in patients with history of isolated and multiple cerebrovascular events

Weissman, Joseph D.; Khunteev, German A.; Heath, Roslyn; Dambinova, Svetlana A.

doi:10.1016/j.jns.2010.09.023

Cited by 71 publications

(48 citation statements)

References 32 publications

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“…The presence of IgG, IgM, and IgA subtypes of autoantibodies has been described [78]. Autoantibodies have also been reported in the serum of patients with stroke, including antineurofilament antibodies [79] and antibodies against the N-NR2A/2B subtype of the N-methyl-D-aspartate receptor (NMDAR) [80,81]. Nevertheless, the presence of some autoantibodies has been described in many different pathological conditions, and also in healthy subjects [82,83], but their clinical significance is not clear.…”

Section: Autoantibodiesmentioning

confidence: 99%

Antigen Presentation After Stroke

et al. 2016

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Section: Autoantibodiesmentioning

confidence: 99%

Antigen Presentation After Stroke

et al. 2016

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“…However, patient 2 also had thrombosis of the femoral vein without previous catheter placement, suggesting that other factors may have contributed to thrombus formation. The specific mechanism underlying the association between anti-NMDAR encephalitis and venous thrombosis remains unknown, but might be partially related to the fact that autoantibodies to NMDAR are associated with a risk of other thrombotic diseases, including stroke, although the causal relationship remains unclear [9,10]. Nevertheless, because NMDAR is expressed in vascular endothelial cells and because its stimulation induces dilation of vessels [11], we speculate that vascular systems are damaged or functionally altered by autoantibodies to NMDAR.…”

Section: Discussionmentioning

confidence: 99%

Details of Treatment-Related Difficulties in Men with Anti-N-Methyl-<smlcap>d</smlcap>-Aspartate Receptor Encephalitis

et al. 2012

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Anti-N-methyl-d-aspartate receptor (anti-NMDAR) antibody-associated encephalitis is an immunologic disease characterized by a female preponderance. Males are infrequently affected. The clinical symptoms of affected boys as well as girls have been summarized, and they have some clinical features distinct from those of adults. However, the characteristics of men have been described in only a few reports. We describe in detail four men with anti-NMDAR encephalitis who presented with several clinical features that complicated disease management and recovery, including venous thrombosis, bilateral hippocampal involvement, hypersexuality, and joint contracture. We also report the first detailed clinical information about a male patient who died of this disease. In addition, we summarize the clinical characteristics of five patients previously reported by others.

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“…Избыточная секре-ция глютамата, вызванная церебральной ишемией, приводит к гиперактивации рецепторов NMDA (N-метил-D-аспартат). Их избыточное количество (в особенности субъединицы NR2) отщепляется сери-новыми протеазами, проходит через ГЭБ, активиру-ет иммунную систему и вызывает образование анти-тел, а присутствие в крови свидетельствует о повы-шенном риске ТИА/инсульта (Weissman et al, 2011;Dambinova et al, 2012).…”

Section: результаты и обсуждениеunclassified

Energy Metabolism of the Brain and Metal-Ligand Homeostasis in the Etiopathogenesis of Ischemic Stroke

Klimenko¹,

Skalny²,

Turna³

et al. 2015

TEM (Moscow)

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11 Институт химической физики им. Н.Н. Семенова РАН, Москва 2 АНО Центр биотической медицины, Москва 3 Институт повышения квалификации ФМБА России, Москва 4 КБ № 123 ФМБА России, Москва РЕЗЮМЕ. В клинических условиях проведено комплексное многофакторное исследование этиопа-тогенеза ишемического инсульта. У пациентов с диагнозом ишемический инсульт с помощью неинва-зивного метода регистрации уровня постоянного потенциала головного мозга отмечена динамика це-ребрального энергообмена на разных этапах ишемического каскада. Одновременно методом эмиссион-ной спектрометрии установлена концентрация макро и микроэлементов в сыворотке крови пациентов и концентрация нейроспецифических белков S100, AT к NR2 и VEGF методом иммуноферментного ана-лиза. Методом дисперсионного анализа по Крускалу−Уоллесу показано достоверное различие концен-трации макро-и микроэлементов и нейроспецифических белков при разных значениях уровня постоян-ного потенциала. С помощью корреляционного анализа выявлены достоверные связи между показате-лями церебрального энергообмена, концентрацией макро-и микроэлементов и нейроспецифических белков, что свидетельствует о возможности использования этих показателей в качестве биомаркеров ишемии мозга с целью обеспечения максимальной сохранности мозговой ткани при дисциркуляцион-ных расстройствах.КЛЮЧЕВЫЕ СЛОВА: ишемический инсульт, мозг, энергетический метаболизм мозга, уровень по-стоянного потенциала, макро-и микроэлементы.

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NR2 antibodies: Risk assessment of transient ischemic attack (TIA)/stroke in patients with history of isolated and multiple cerebrovascular events

Cited by 71 publications

References 32 publications

Antigen Presentation After Stroke

Antigen Presentation After Stroke

Details of Treatment-Related Difficulties in Men with Anti-N-Methyl-<smlcap>d</smlcap>-Aspartate Receptor Encephalitis

Energy Metabolism of the Brain and Metal-Ligand Homeostasis in the Etiopathogenesis of Ischemic Stroke

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