“…These target genes, including FOS, COL11A2, PRSS50, NR4A1, CHI3L1, FBLN1, FOXA1, EPOR, LCAT, ABCC6, SLC22A6, MMP7, PCK2 and ASS1, are also differentially expressed in human CKD kidney. Among these genes, some are reported to be related to renal brosis, such as MMP7, NR4A1, LCAT and so on [51][52][53] . At the same time, ROC analysis reveals that transcription factor CREB1, FOS, HIF1A and SP1 have higher diagnostic e cacy than HNF4A and CEBPA.…”