Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats

Alsabaani, Nasser A.; Amawi, Kawther; Eleawa, Samy M.; Nabeel Ibrahim, Wisam; Aldhaban, Walid; Alaraj, Ahmad Mohammad; Alkhalaf, Badr; Sami, Waqas; Alshaikhli, Hisham; Alkhateeb, Mahmoud A.

doi:10.1016/j.biopha.2024.116461

Cited by 2 publications

(2 citation statements)

References 77 publications

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“…Recently, Esculeoside A (ESA), a tomato-derived glycoside, has been shown to alleviate retinopathy in an in-vivo rat model of T1DM. The protective mechanism is found to be mediated by the Nrf2/antioxidant axis ( 225 ). Overall, research on the drugs that could reduce oxidative stress and inflammation likely help maintain the cellular and molecular integrity of the neurovascular unit, and research along these lines is necessary to prevent complications and vision loss associated with DR.…”

Section: Advancing Therapies For Treating Diabetic Retinopathymentioning

confidence: 99%

Cell and molecular targeted therapies for diabetic retinopathy

Reddy,

Devi,

Seetharaman

et al. 2024

Front. Endocrinol.

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Diabetic retinopathy (DR) stands as a prevalent complication in the eye resulting from diabetes mellitus, predominantly associated with high blood sugar levels and hypertension as individuals age. DR is a severe microvascular complication of both type I and type II diabetes mellitus and the leading cause of vision impairment. The critical approach to combatting and halting the advancement of DR lies in effectively managing blood glucose and blood pressure levels in diabetic patients; however, this is seldom achieved. Both human and animal studies have revealed the intricate nature of this condition involving various cell types and molecules. Aside from photocoagulation, the sole therapy targeting VEGF molecules in the retina to prevent abnormal blood vessel growth is intravitreal anti-VEGF therapy. However, a substantial portion of cases, approximately 30–40%, do not respond to this treatment. This review explores distinctive pathophysiological phenomena of DR and identifiable cell types and molecules that could be targeted to mitigate the chronic changes occurring in the retina due to diabetes mellitus. Addressing the significant research gap in this domain is imperative to broaden the treatment options available for managing DR effectively.

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Section: Advancing Therapies For Treating Diabetic Retinopathymentioning

confidence: 99%

Cell and molecular targeted therapies for diabetic retinopathy

Reddy,

Devi,

Seetharaman

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

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“…Nrf2 mitigates oxidative stress-induced damage to ocular tissues by activating antioxidant enzymes that eliminate harmful reactive oxygen species and free radicals. It suppresses the production of inflammatory mediators, reducing ocular inflammatory responses, while also promoting the repair of damaged cells and the regeneration of retinal tissue, maintaining the integrity of ocular structures ( 55 ). Nrf2 also regulates cellular metabolic pathways, affecting the synthesis and breakdown of fatty acids, influencing the progression of metabolic diseases, and providing protective effects on retinal neurons, reducing neurodegeneration, and preserving visual function ( 56 ).…”

Section: Characteristics Of Ferroptosismentioning

confidence: 99%

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

Yang,

Lin,

Han

et al. 2024

Front. Immunol.

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Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation and differs from programmed cell death, such as apoptosis, necrosis, and autophagy. Ferroptosis is associated with a variety of physiological and pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence and development of diseases by targeting metabolic pathways and signaling pathways in tumors, ischemic organ damage, and other degenerative diseases related to lipid peroxidation. Increasing evidence suggests that ferroptosis is closely linked to the onset and progression of various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, and retinoblastoma. Our review of the current research on ferroptosis in ophthalmic diseases reveals significant advancements in our understanding of the pathogenesis, aetiology, and treatment of these conditions.

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Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats

Cited by 2 publications

References 77 publications

Cell and molecular targeted therapies for diabetic retinopathy

Cell and molecular targeted therapies for diabetic retinopathy

Ferroptosis: a novel mechanism of cell death in ophthalmic conditions

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