Nrf2 Activator PB125<sup>®</sup>as a Potential Therapeutic Agent Against COVID-19

McCord, Joe M.; Hybertson, Brooks M.; Cota‐Gomez, Adela; Gao, Bifeng

doi:10.1101/2020.05.16.099788

Cited by 34 publications

(16 citation statements)

References 66 publications

(77 reference statements)

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“…This leads to the activation of host antioxidant pathways including nuclear factor erythroid 2p45-related factor 2 (Nrf2) (Lee 2018). Nrf2 transcription factor is known to control the expression of various genes involved in antiviral actions (McCord et al 2020). A study conducted by McCord and colleagues showed that potent Nrf2 activation by PB125 ® compound downregulated ACE2 and TMPRSS2 mRNA expression in human liver-derived HepG2 cells.…”

Section: Garlic Oilmentioning

confidence: 99%

COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties

et al. 2020

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Coronavirus disease of 2019 (COVID-19) has emerged as a global health threat. Unfortunately, there are very limited approved drugs available with established efficacy against the SARs-CoV-2 virus and its inflammatory complications. Vaccine development is actively being researched, but it may take over a year to become available to general public. Certain medications, for example, dexamethasone, antimalarials (chloroquine/hydroxychloroquine), antiviral (remdesivir), and IL-6 receptor blocking monoclonal antibodies (tocilizumab), are used in various combinations as off-label medications to treat COVID-19. Essential oils (EOs) have long been known to have anti-inflammatory, immunomodulatory, bronchodilatory, and antiviral properties and are being proposed to have activity against SARC-CoV-2 virus. Owing to their lipophilic nature, EOs are advocated to penetrate viral membranes easily leading to membrane disruption. Moreover, EOs contain multiple active phytochemicals that can act synergistically on multiple stages of viral replication and also induce positive effects on host respiratory system including bronchodilation and mucus lysis. At present, only computer-aided docking and few in vitro studies are available which show anti-SARC-CoV-2 activities of EOs. In this review, role of EOs in the prevention and treatment of COVID-19 is discussed. A discussion on possible side effects associated with EOs as well as anti-corona virus claims made by EOs manufacturers are also highlighted. Based on the current knowledge a chemo-herbal (EOs) combination of the drugs could be a more feasible and effective approach to combat this viral pandemic.

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Section: Garlic Oilmentioning

confidence: 99%

COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties

et al. 2020

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“…In this context, a vicious cycle of demethylation and augmented oxidative stress could increase susceptibility to SARS-CoV-2 infection [129]. Moreover, the antioxidant capacity is usually lost with age, and this pro-oxidative state associated with aging could be one of the reasons for which elderly people are more susceptible to being affected by SARS-CoV-2 infection [130][131][132].…”

Section: Interrelation Among Oxidative Stress Raas and Sars-cov-2 Imentioning

confidence: 99%

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

et al. 2020

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Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has put the health of the world population on alert. COVID-19 can provoke an acute inflammatory process and uncontrolled oxidative stress, which predisposes one to respiratory syndrome, and in the worst case, death. Recent evidence suggests the mechanistic role of mitochondria and vitamin D in the development of COVID-19. Indeed, mitochondrial dynamics contribute to the maintenance of cellular homeostasis, and its uncoupling involves pathological situations. SARS-CoV-2 infection is associated with altered mitochondrial dynamics with consequent oxidative stress, pro-inflammatory state, cytokine production, and cell death. Furthermore, vitamin D deficiency seems to be associated with increased COVID-19 risk. In contrast, vitamin D can normalize mitochondrial dynamics, which would improve oxidative stress, pro-inflammatory state, and cytokine production. Furthermore, vitamin D reduces renin–angiotensin–aldosterone system activation and, consequently, decreases ROS generation and improves the prognosis of SARS-CoV-2 infection. Thus, the purpose of this review is to deepen the knowledge about the role of mitochondria and vitamin D directly involved in the regulation of oxidative stress and the inflammatory state in SARS-CoV-2 infection. As future prospects, evidence suggests enhancing the vitamin D levels of the world population, especially of those individuals with additional risk factors that predispose to the lethal consequences of SARS-CoV-2 infection.

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“…ARDS caused by SARS-Cov2 is followed by alveolar cells damage and lung fibrosis and the host immune response (with cytokine storm) and inflammation is a crucial determinant of disease outcome. Cytokine [26]. Nrf2 activation reduce lung cells damage in COVID-19 patients and Inhibits virus penetration.…”

Section: Discussionmentioning

confidence: 99%

The effect of Co-Q10 on allergic rhinitis and allergic asthma

Meng

Athari

et al. 2021

Allergy Asthma Clin Immunol

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Background Allergic asthma is an inflammatory disease resulting from continued or intermittent allergen exposure, and allergic rhinitis can be trigger of asthma. The main mechanism of these disease is allergic reaction and immune response dysregulation. Co-Q10 is an enzyme cofactor in mitochondria can control asthma and allergic rhinitis symptoms. In the present study, we determined that the CoQ10-induced anti-allergic effects were mediated by up-regulation of Nrf2. Methods Animal models of allergic rhinitis and allergic asthma were produced and treated with Co-Q10, Co-Q10 and O-3, Co-Q10 and Mg-S. Bronchoalveolar lavage fluid was collected from animal models, and IL-4, 5, 13, INF-y, Eicosanoids, IgE, EPO, and histamine production were measured. Also, COX-2, CCL24, CCL11, Nrf2, Eotaxin, Cytb, COX1 and ND1 genes expressions and histopathology were studied. BALf's cells were collected by tracheostomy and used in slide producing by cytospine. Cytokines, Eicosanoids, IgE, EPO, and histamine were measured by ELISA method. Gene expression was done by Real-time PCR. Results Co-Q10 with two supplementation (Mg-S and O-3) modulate MRC, BALf eosinophils, eosinophilic inflammation related genes (eotaxin, CCL11 and CCL24), peribronchial and perivascular inflammation, EPO, type 2 cytokines (IL-4, 5 and 13), IgE, histamine, Cyc-LT and LTB4 as main allergic bio-factors. Importantly, Co-Q10 treatment increased Nrf2 expression and Nrf2 induced antioxidant genes, glutathione redox and inhibited inflammation, oxidative stress injury, Th2 cytokines production and attenuated allergic inflammatory responses. Conclusion Nrf2 is activated in response to allergen, induces resistance against the rhinitis and asthma development and plays an essential role in broncho-protection. Co-Q10 increases the Nrf2 expression and the Nrf2 over-expression has strong effect in control of type2 cytokines, allergic mediators and inflammatory factors that lead to harnessing of allergy and asthma. Graphic abstract

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Nrf2 Activator PB125^®as a Potential Therapeutic Agent Against COVID-19

Cited by 34 publications

References 66 publications

COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties

COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

The effect of Co-Q10 on allergic rhinitis and allergic asthma

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Nrf2 Activator PB125®as a Potential Therapeutic Agent Against COVID-19

Cited by 34 publications

References 66 publications

COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties

COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties

Implications of Oxidative Stress and Potential Role of Mitochondrial Dysfunction in COVID-19: Therapeutic Effects of Vitamin D

The effect of Co-Q10 on allergic rhinitis and allergic asthma

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Nrf2 Activator PB125^®as a Potential Therapeutic Agent Against COVID-19