Nrf2: Its Newly Discovered Machineries

Bird, Harper Z.; Hopkins, Robert Z.

doi:10.20455/ros.2016.863

Search citation statements

Order By: Relevance

Paper Sections

Select...

Regulation Of Ao/ai Genes By D3t In Multiple Organs1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, Nrf2 may not function solely as a regulator of AO/AI genes. Indeed, studies show that Nrf2 signaling plays a critical role in tissue homeostasis (e.g., tissue repair and immune modulation) independent of its well-known function—as a transcriptional activator of cellular antioxidant genes [13, 14].…”

Section: Regulation Of Ao/ai Genes By D3t In Multiple Organsmentioning

confidence: 99%

3H-1,2-Dithiole-3-Thione as a Potentially Novel Therapeutic Compound for Sepsis Intervention

Li¹,

Jia²,

Zhu

2019

ROS

View full text Add to dashboard Cite

Through the history of modern medicine, bioactive components in natural products have been either employed directly as medicines or used as prototypes for synthetic drug development. This brief Research Highlights paper considers 3H-1,2-dithiole-3-thione (D3T), a member of the 1,2-dithiole-3-thiones—compounds which may naturally occur in cruciferous vegetables. Among 1,2-dithiole-3-thiones, D3T is the most potent member with regard to the capacity of inducing tissue defenses against oxidative and inflammatory stress. Oxidative and inflammatory stress is a major pathophysiological process involved in numerous human disorders, including cancer, cardiovascular diseases, neurodegeneration, and sepsis, to name just a few. This article surveys recent major research findings on D3T as an inducer of tissue antioxidative and antiinflammatory defenses and as a potential therapeutic modality for sepsis intervention.

show abstract

Section: Regulation Of Ao/ai Genes By D3t In Multiple Organsmentioning

confidence: 99%