Nrf2-mediated macrophage function in benign prostatic hyperplasia: Novel molecular insights and implications

Song, Guanhui; Tong, Jinlin; Wang, Yuhe; Li, Yuanyuan; Liao, Zeqi; Fan, Danping; Fan, Xinrong

doi:10.1016/j.biopha.2023.115566

Biomedicine & Pharmacotherapy

2023

DOI: 10.1016/j.biopha.2023.115566

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Nrf2-mediated macrophage function in benign prostatic hyperplasia: Novel molecular insights and implications

Guanhui Song,

Jinlin Tong,

Yuhe Wang

et al.

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Cited by 2 publications

References 51 publications

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Portulaca oleracea Extract Ameliorates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in Male Sprague‐Dawley Rats

Lim,

Kim,

Lee

et al. 2024

Veterinary Medicine & Sci

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Benign prostatic hyperplasia (BPH) is a distressing health problem that can cause serious complications in aging men. Androgens are implicated in the causation of BPH. Portulaca oleracea (PO) is a natural product with diverse pharmacological effects. The objective of this study was to investigate the effect of PO in a rat model of testosterone propionate (TP)‐induced BPH and explore the underlying mechanisms. Thirty‐five Sprague‐Dawley (SD) rats were divided into the following equal groups (n = 7): normal control (NC) group, TP (3 mg/kg) group, finasteride (10 mg/kg) group, 25 and 50 mg/kg PO groups.At the end of the experiment, the body weights (BWs) of the rats were measured before they were euthanized to the establishment obtain serum and prostate weight (PW). TP‐induced levels of androgen‐related proteins in the prostate were also investigated. In the TP group, prostate size, BW, serum DHT level, prostate epithelial cell thickness and androgen‐related protein level were higher than those in the NC group (p < 0.001). PO reversed TP‐induced BPH in a dose‐dependent manner (p < 0.01) and its effect was similar to that of finasteride. A similar effect of PO on the androgen‐related protein level was also observed. We successfully established a TP‐induced BPH rat model. This is the first study to demonstrate that inhibition of androgen‐related proteins using PO can alleviate BPH.

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Portulaca oleracea Extract Ameliorates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in Male Sprague‐Dawley Rats

Lim,

Kim,

Lee

et al. 2024

Veterinary Medicine & Sci

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Purple corn extract improves benign prostatic hyperplasia by inhibiting 5 alpha-reductase type 2 and inflammation in testosterone propionate-induced rats

Kim,

Choi,

Lee

et al. 2025

Front. Pharmacol.

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Benign prostatic hyperplasia (BPH) is a health issue caused by an enlarged prostate in older men. Its prevalence increases with age, and it results in urination-related problems. This works studied the effect of purple corn extract (PCE) on improving BPH symptoms using a testosterone propionate (TP)-induced rat model. PCE reduced the enlargement and weight of the prostate through the inhibition of the conversion of testosterone to dihydrotestosterone (DHT) by inhibiting 5α-reductase type 2 (Srd5a2) in TP-induced BPH rats. In these rats, PCE decreased androgen receptor (AR) expression, AR-mediated signaling, and cell proliferation and increased apoptotic cell death. Finally, PCE exhibited anti-inflammatory activity through the regulation of the nuclear factor-kappa B (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf-2) axis. These results indicate that the Srd5a2 inhibition and anti-inflammatory activity are some of the beneficial effects of PCE that improve BPH symptoms.

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Nrf2-mediated macrophage function in benign prostatic hyperplasia: Novel molecular insights and implications

Cited by 2 publications

References 51 publications

Portulaca oleracea Extract Ameliorates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in Male Sprague‐Dawley Rats

Portulaca oleracea Extract Ameliorates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in Male Sprague‐Dawley Rats

Purple corn extract improves benign prostatic hyperplasia by inhibiting 5 alpha-reductase type 2 and inflammation in testosterone propionate-induced rats

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