Nrf2 Silencing for Neuron Maturation

Hopkins, Robert Z.

doi:10.20455/ros.2016.809

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Alternatively, doxorubicin may directly bind to the Nrf2 sequestering protein, Keap1, causing its degradation. Regardless of the molecular mechanisms involved, stimulation of Nrf2 signaling by doxorubicin is not unexpected as activation of the Nrf2 pathway is a common adaptive response to oxidants as well as many other stress factors [15–17]. …”

Section: Oxidative Stressmentioning

confidence: 99%

Doxorubicin Redox Biology: Redox Cycling, Topoisomerase Inhibition, and Oxidative Stress

Zhu

Sarkar

Scott

et al. 2016

ROS

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Doxorubicin (also called Adriamycin) is effective in treating a wide range of human cancers and currently considered as one of the most important drugs in cancer chemotherapeutics. The clinical use of doxorubicin is, however, associated with dosage-dependent cardiotoxicity and development of heart failure, which diminish the therapeutic index of this widely used anticancer drug. This article first surveys key research findings on doxorubicin redox biology that may impact its cardiotoxicity as well as anticancer activity. It then discusses emerging concepts, especially the topoisomerase IIb–p53–mitochondrion axis that may lead to the development of mechanistically based novel strategies to protect against cardiotoxicity and enhance the effectiveness of doxorubicin therapy.

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Section: Oxidative Stressmentioning

confidence: 99%

Doxorubicin Redox Biology: Redox Cycling, Topoisomerase Inhibition, and Oxidative Stress

Zhu

Sarkar

Scott

et al. 2016

ROS

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“…Since mitochondria are the major sites of O 2 consumption (≈90%), they are the key sources of internal ROS production. [ 40 ] In a natural state, the electron leakage from mitochondrial complex I (NADH: ubiquinone oxidoreductase) and complex III (ubiquinol:cytochrome c oxidoreductase) is about 1% of the leakage, and this leakage can upsurge during the oxidative stress and cause a toxic ROS accumulation. [ 41 ] Being one of the leading sites of electron leakage, complex I is most accountable for producing superoxide (O 2 − ).…”

Section: Ros and Bio‐functional Supplements From Microalgaementioning

confidence: 99%

Microalgae‐Derived Health Supplements to Therapeutic Shifts: Redox‐Based Study Opportunities with AIE‐Based Technologies

Reza

Zhu

Qin

et al. 2021

Adv Healthcare Materials

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Reactive oxygen species (ROS) are highly reactive molecules, serve the normal signaling in different cell types. Targeting ROS as the chemical signals, different stress based strategies have been developed to synthesis different anti‐inflammatory molecules in microalgae. These molecules could be utilized as health supplements in human. To provoke the ROS‐mediated defence systems, their connotation with the associated conditions must be well understood, therefore, proper tools for studying ROS in natural state are essential. The in vivo detection of ROS with phosphorescent probes offers promising opportunities to study these molecules in a non‐invasive manner. Most of the common problems in the traditional fluorescent probes are lower photostability, excitation intensity, slow responsiveness, and the microenvironment that challenge their performance. Some ROS‐specific aggregationinduced emission luminogens (AIEgens) with pronounced spatial and temporal resolution have recently demonstrated high selectivity, rapid responsiveness, and efficacies to resolve the aggregation‐caused quenching issues. The nanocomposites of some AIE‐photosensitizers can also improve the ROS‐mediated photodynamic therapy. These AIEgens could be used to induce bioactive components in microalgae through altering the ROS signaling, therefore are more auspicious for biomedical research. This study reviews the prospects of AIEgen‐based technologies to understand the ROS mediated bio‐physiological processes in microalgae for better healthcare benefits.

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Nrf2 Silencing for Neuron Maturation

Cited by 2 publications

References 15 publications

Doxorubicin Redox Biology: Redox Cycling, Topoisomerase Inhibition, and Oxidative Stress

Doxorubicin Redox Biology: Redox Cycling, Topoisomerase Inhibition, and Oxidative Stress

Microalgae‐Derived Health Supplements to Therapeutic Shifts: Redox‐Based Study Opportunities with AIE‐Based Technologies

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