NS1 Antigen Capture ELISA an Effective Method for Diagnosis of Early Dengue Infection - Report of an Outbreak at Angul District, Odisha, India

Mahapatra, Dharitri; Sarangi, Gitanjali; Mahapatra, Ashoka; Paty, Bimoch Projna; Das, Padma; Chayani, Nirupama

doi:10.7860/jcdr/2014/8589.4697

Cited by 11 publications

(9 citation statements)

References 13 publications

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“…[ 10 ] The major diagnostic methods available presently are viral culture, viral nucleic acid detection by recombinant polymerase chain reaction, and serological tests such as IgM capture enzyme-linked immunosorbent assay (ELISA). [ 11 ] After the onset of illness, the virus can be detected in serum, plasma, circulating blood cells, and other tissues for 4-5 days. During the early stages of the disease, virus isolation, nucleic acid or antigen detection can be used to diagnose the infection that gives a definitive diagnosis of dengue.…”

Section: Discussionmentioning

confidence: 99%

Can radiology play a role in early diagnosis of dengue fever?

Chandak

Kumar

2016

North Am J Med Sci

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Background:Dengue fever (DF) is a viral hemorrhagic fever causing severe morbidity and mortality in affected patients.Aims:The purpose of our study was to evaluate the changing trends in radiological findings in DF, to find if ultrasound is useful in the diagnosis of DF during an epidemic in absence of serological tests, and also to investigate the effects of DF in pregnancy.Materials and Methods:A prospective study was conducted in 2013 comprising of 400 patients who were serologically positive for dengue. Out of these, radiological investigations were conducted for 107 patients who were analyzed.Results:Out of the 107 patients, 85 patients underwent ultrasound, 12 computed tomography (CT) scans of brain or paranasal sinuses, and 21 chest radiography. The maximum numbers of patients (79%) were in the age group of 20-50 years. The most common ultrasound finding was hepatomegaly that was seen in 62% of the patients. Other findings were splenomegaly (45%), gallbladder (GB) wall edema (45%), right-sided pleural effusion (37%), bilateral pleural effusion (22%), and ascites (36%). Out of 10 pregnant patients, 5 had oligohydramnios, 2 had intrauterine growth restriction, 2 had intrauterine fetal demise, and 5 had a normal antenatal ultrasound.Conclusion:Ultrasound findings of hepatosplenomegaly, GB wall edema, right-sided or bilateral pleural effusion, and ascites in patients presenting with signs and symptoms of DF during an epidemic are virtually diagnostic of DF. There have been recent changing trends with hepatosplenomegaly being the more common manifestation, in comparison to ascites and GB wall edema. DF also has catastrophic effects in pregnancy such as oligohydramnios and intrauterine fetal demise.

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Section: Discussionmentioning

confidence: 99%

Can radiology play a role in early diagnosis of dengue fever?

Chandak

Kumar

2016

North Am J Med Sci

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“…The diagnosis of dengue using NS1Ag has been shown to have acceptable accuracy, with sensitivity of 88% during the first 5 days but declining to 7% during days 6 to 10, and 100% specificity (9,10). Therefore, our study aimed to determine the clinical presentations of dengue in Thai adults who had positive NS1Ag and to identify predictive factors for severe dengue.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

A Multicenter Study of Clinical Presentations and Predictive Factors for Severe Manifestation of Dengue in Adults

et al. 2018

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“…Overall findings in this study again confirms that NS1 Ag test is useful in diagnosing dengue virus infection during the early symptomatic phase, the same is observed by Suleman. M. [9] and Mahapatra D [10] . But the correlation with early detection is not useful to identify severity.…”

Section: Discussionmentioning

confidence: 99%

The Value of DNS1 Antigen for Early Detection of Dengue Infection in Children: The Changing Sensitivity

Rajendran¹

2018

jmscr

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NS1 Antigen Capture ELISA an Effective Method for Diagnosis of Early Dengue Infection - Report of an Outbreak at Angul District, Odisha, India

Cited by 11 publications

References 13 publications

Can radiology play a role in early diagnosis of dengue fever?

Can radiology play a role in early diagnosis of dengue fever?

A Multicenter Study of Clinical Presentations and Predictive Factors for Severe Manifestation of Dengue in Adults

The Value of DNS1 Antigen for Early Detection of Dengue Infection in Children: The Changing Sensitivity

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