NSAID use in orthopedic surgery: A review of current evidence and clinical practice guidelines

Abstract

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are a valuable class of medications for orthopedic surgeons and often play a pivotal role in pain control. However, there are many common stipulations resulting in avoidance of its use in the treatment of musculoskeletal disease. This review summarizes the mechanism of action of NSAIDs as well as provides an overview of commonly used NSAIDs and the differences between them. It provides a concise summary on the osseous effects of NSAIDs with regard to bone healing and heterotopic ossification. Most of all, it serves as a guide or reference for orthopedic providers when counseling patients on the risks and benefits of NSAID use, as it addresses the common stipulations encountered: “It irritates my stomach,” “I have a history of bariatric surgery,” “I'm already on a blood thinner,” “I've had a heart attack,” and “I've got kidney problems” and synthesizes both current research and society recommendations regarding safe use and avoidance of NSAIDs.

Exploring the Anti-inflammatory and Anti-Arthritic Potential of Malus peel Phenolics: A comprehensive comparative analysis of Royal delicious, Delicious, Golden delicious, andMaharaji Cultivars from Kashmir, India

“…Pharmacologists from all around the world have been concentrating their efforts on developing more effective and safe in ammation suppressive medications. Non-steroidal antiin ammatory medications (NSAIDs) and corticosteroids and are the pharmaceuticals most frequently used to treat in ammatory and arthritic disorders [13]. Nonsteroidal anti-in ammatory drugs (NSAIDs) have been shown to be effective in treating rheumatoid disorders and in ammation not only because they are prostaglandins antagonists, but also because they have the ability to stabilize cell and lysosomal membranes as well as safeguard intrinsic proteins from denaturation, which can result in the formation of peptides that are thought to be autoantigens triggering rheumatism but the biggest drawback of the powerful synthetic corticosteroids and NSAIDs now on the market is their toxicity and recurrence of indications after stopping use [14].…”