nterrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes

Hurina, NM; Корпачева-Зиныч, О В; Shuprovych, AA

doi:10.15407/fz56.06.093

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…We also observed an association between uric acid and hypogonadism in our study consistent with the findings of other studies that uric acid was negatively correlated with testosterone levels in patients with T2DM (22,23). A previous study also reported decreased mean testosterone levels in patients with gouty kidney disease and gouty arthritis (33). It was reported that the relationship between uric acid and testosterone levels were bidirectional.…”

Section: Discussionsupporting

confidence: 92%

Incidence and Risk Factors of Hypogonadism in Male Patients With Latent Autoimmune Diabetes and Classic Type 2 Diabetes

et al. 2021

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ObjectivesThis study aimed to compare the prevalence of hypogonadism between male patients with latent autoimmune diabetes (LADA) and type 2 diabetes (T2DM) and investigate the risk factors for hypogonadism in these patients.MethodsThis cross-sectional study evaluated 367 male patients with LADA (n=73) and T2DM (n=294) who visited the endocrinology department of Shanghai Tenth People’s Hospital between January 2016 and October 2019 for diabetes management. Sex hormones, lipid profiles, sex hormone-binding globulin (SHBG), glycosylated hemoglobin A1c, beta-cell function, uric acid, and osteocalcin were determined in serum samples. Hypogonadism was defined as calculated free testosterone (cFT) less than 220 pmol/L along with the presence of symptoms (positive ADAM score).ResultsThe rate of hypogonadism in the LADA and T2DM group were 8.2, and 21.7%, respectively (p=0.017). After adjusting possible confounders, the rate of hypogonadism in the LADA group was comparable to those of the T2DM group. Univariate logistic regressions demonstrated that age, BMI, fasting C-peptide, triglycerides, total cholesterol and uric acid were associated with hypogonadism in men with diabetes, BMI, triglycerides and estradiol were independent risk for hypogonadism in men with diabetes.ConclusionThis is the first evidence to explore the rate of hypogonadism in male patients with latent autoimmune diabetes (LADA). In the population requiring admission to a large urban hospital in China, the rate of hypogonadism was comparable to those of the T2DM group after adjusting for possible confounders. BMI, triglycerides and estradiol were independently associated with the presence of HH in male diabetic patients.

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Section: Discussionsupporting

confidence: 92%

Incidence and Risk Factors of Hypogonadism in Male Patients With Latent Autoimmune Diabetes and Classic Type 2 Diabetes

et al. 2021

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“…Furthermore, testosterone replacement treatment improves metabolic measures in obese subjects [22]. Indeed, production of testosterone was reported to be reduced in patients with gout and gouty arthritis [23]. Insulin resistance, which is a feature of T2DM, was suggested to be related to hyperuricemia [24,25].…”

Section: Discussionmentioning

confidence: 99%

Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus

et al. 2019

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Aim: Despite it has some disadvantages, the most important marker of diabetic control is glycated hemoglobin (HbA1c). Uric acid to HDL cholesterol ratio (UHR) is a promising marker in metabolic syndrome. We aimed to compare UHR levels of well and poorly controlled type 2 diabetic male subjects, as well as healthy men, and to observe its correlation with other metabolic parameters. Methods: Male patients with T2DM that showed up in outpatient internal medicine clinics of our hospital were enrolled to the study. Diabetic subjects divided into two groups according to the level of HbA1c: well-controlled T2DM group (HbA1c < 7%) and poorly controlled T2DM group (HbA1c 7%). Third group was consisted of healthy subjects without any chronic diseases. UHR levels of the groups were compared. Results: The UHR levels of well and poorly controlled diabetics and control subjects were 12%±5%, 17%±6% and 9%±3%, respectively (p<.001). The UHR was significantly and inversely correlated with GFR and was significantly and positively correlated with waist circumference, body weight, body mass index, serum creatinine, fasting plasma glucose (FPG) and HbA1c levels. Conclusion: UHR could serve as a promising predictor of diabetic control in men with T2DM, since it has significant association with HbA1c and FPG levels.

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“…In the present study, an inverse association was observed between TT levels and uric acid levels among men with type 2 diabetes. A previous study has found decreased testosterone and estradiol synthesis in male patients with gout; patients with gouty kidney disease and gouty arthritis showed a significant decrease in testosterone levels [ 24 ]. The reasons may include (1) crystallization of uric acid in the testicular tissue causing oxidative damage [ 25 ] and (2) insulin resistance that can be reduced by low testosterone levels [ 26 ], results in reduced secretion of uric acid in renal tubular epithelial cells after absorption and the renal excretion of uric acid [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes

Cao

Ruan

et al. 2017

International Journal of Endocrinology

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The association between serum uric acid (SUA) level and sexual dysfunction in patients with diabetes is not well characterized. Type 2 diabetes mellitus (T2DM) causes metabolic disorders, including abnormal serum uric acid (SUA) levels. In this study, we enrolled 205 male patients with T2DM and investigated the relationship between sex hormone levels and SUA. Patients were divided into four groups based on SUA quartiles. On the other hand, based on the total testosterone (TT) level, patients were divided into three groups; SUA and other laboratory indices were determined. Increase in SUA level was significantly associated with decreased levels of TT, luteinizing hormone, follicle-stimulating hormone, sex hormone-binding globulin, and increased levels of dehydroepiandrosterone, age, body mass index (BMI), waist circumference, glycated hemoglobin, serum creatinine, and HOMA-IR levels. SUA, waist circumference, BMI, and HOMA-IR showed a negative correlation with TT level, while age showed a positive correlation with TT level. SUA and body mass index were found to be risk factors for gonadal dysfunction. Therefore, we conclude that hypogonadism of male patients with T2DM is related to SUA level.

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nterrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes

Cited by 4 publications

References 17 publications

Incidence and Risk Factors of Hypogonadism in Male Patients With Latent Autoimmune Diabetes and Classic Type 2 Diabetes

Incidence and Risk Factors of Hypogonadism in Male Patients With Latent Autoimmune Diabetes and Classic Type 2 Diabetes

Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus

Association between Sex Hormone and Blood Uric Acid in Male Patients with Type 2 Diabetes

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