NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of methanol

Shelby, Michael D.; Portier, Christopher J.; Goldman, Lynn R.; Moore, J. A.; Iannucci, Annette R.; Jahnke, Gloria D.; Donkin, Steve; Panel, Ntp-Cerhr Expert

doi:10.1016/j.reprotox.2003.10.013

Cited by 30 publications

(5 citation statements)

References 118 publications

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“…Phthalates are high-production chemicals [1] with global manufacturing exceeding 11 billion tons annually [2]. Phthalates are extremely versatile and therefore are used in a wide range of industrial products, including plastics, personal care products, packaging, insecticides, pesticides, and medical devices [3][4][5][6]. Phthalates are not chemically bound to the products they modify and can easily leach into the environment via wastewater, industrial releases, manufacturing disposal, and breakdown from products containing phthalates [1,7].…”

Section: Introductionmentioning

confidence: 99%

Temporal and Spatial Evaluation of Mono(2-ethylhexyl) Phthalate (MEHP) Detection in Common Bottlenose Dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA

Dziobak

Balmer²,

Wells

et al. 2022

Oceans

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Phthalates are endocrine-disrupting chemicals added to plastics, personal care products, cleaning solutions, and pesticides. Extensive use has led to its exposure to wildlife, including common bottlenose dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA; however, there are gaps in knowledge regarding whether sample timing or geographic location influence exposure. Dolphins were evaluated for temporal and spatial variability in urinary mono(2-ethylhexyl) phthalate (MEHP) detection (2010–2019). Significant fluctuations in detectable MEHP concentrations were found across the dataset. All samples from 2014 and 2015 (n = 12) had detectable MEHP concentrations; thus, data were classified into cohorts to explore the significance of prevalent MEHP detection (“Cohort 1” (n = 10; 2010–2013), “Cohort 2” (2014–2015), and “Cohort 3” (n = 29; 2016–2019)). Compared to Cohorts 1 and 3, Cohort 2 had higher detectable MEHP concentrations (Dunn’s; p = 0.0065 and p = 0.0012, respectively) and a greater proportion of detectable MEHP concentrations (pairwise comparisons using Benjamini–Hochberg adjustments: p = 0.0016 and p = 0.0059, respectively). MEHP detection also varied across spatial scales. Dolphins with detectable MEHP concentrations had ranges primarily within enclosed embayments, while dolphins with nondetectable MEHP concentrations extended into open waters, potentially indicating geographically linked exposure risk. This study suggests that researchers and management agencies should consider a population’s ranging pattern, geographic habitat characteristics, and sample timing when assessing small cetacean health in relation to contaminant exposure.

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Section: Introductionmentioning

confidence: 99%

Temporal and Spatial Evaluation of Mono(2-ethylhexyl) Phthalate (MEHP) Detection in Common Bottlenose Dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA

Dziobak

Balmer²,

Wells

et al. 2022

Oceans

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“…Taking advantage of industrial alcohol to produce shoddy edible wine in a fake way presumably may cause methanol poisoning. 2,3 Besides, methanol vapors can also injure the nervous tissue and connective tissue of mammals. 4,5 Hence, rapid, accurate, and effective detection of methanol and its vapor is tremendously significant and necessary for ensuring food safety, maintaining public social safety, and protecting human health.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Industrial alcohol contains about 4% of methanol. Taking advantage of industrial alcohol to produce shoddy edible wine in a fake way presumably may cause methanol poisoning. , Besides, methanol vapors can also injure the nervous tissue and connective tissue of mammals. , Hence, rapid, accurate, and effective detection of methanol and its vapor is tremendously significant and necessary for ensuring food safety, maintaining public social safety, and protecting human health. − Various methods for detection of methanol and its vapor have been exploited, such as high-performance liquid and gas chromatography; infrared (IR), H 1 NMR, electrochemical, enzymatic techniques; gas sensors, and so forth. − However, high cost, inconvenience, and special equipment obstruct the application of these methods in actual sensing. Therefore, it is imperative to procure a rapid, less-consumed, and easy-to-use method to identify and respond to methanol or its vapor.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembly of Lanthanide-Based Metallogel Nanoplates into Microcubic Blocks as Self-Calibrating Luminescent Methanol Sensors

Yang

Liu

Zhong

et al. 2021

ACS Appl. Nano Mater.

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Because of the serious physiological toxicity of methanol, detection of methanol in ethanol medium is tremendously significant. Herein, excellent luminescent lanthanide-based supramolecular metallogels were prepared with the conventional low-molecular-weight-gelator 1,3,5-benzenetricarboxylic acid (BTC) and the lanthanide trivalent cations (Tb 3+ and Eu 3+ ), which exhibit distinctive characteristic photoluminescent emission of lanthanides. These metallogels were synthesized depending on the one-step method of a high-concentration reaction synergized with heat-assisted ultrasound. The mechanical characteristics of the supramolecular metallogels were investigated through a rheological study. The scanning electron microscopy study revealed the supramolecular interconnection structure of microcubic blocks formed through irregular self-assembly of nanoplates. The bi-metallogel (Eu/Tb-G) with an obvious brilliant yellow emission signal was favorably fabricated via utilizing the lanthanide co-doping strategy and manifests the characteristic emission bands of lanthanide trivalent ions (Eu 3+ and Tb 3+ ) simultaneously. The energy-transfer behavior between Tb 3+ and Eu 3+ was systematically studied. What is striking is that methanol facilitates the increase of Tb 3+ fluorescence intensity without affecting the characteristic emission of Eu 3+ , and this phenomenon induces a unique emission proportion between Tb 3+ and Eu 3+ ions. Inspired by this, a self-calibrated fluorescence sensor of methanol is acquired, which adopts the dynamic emission of Tb 3+ that can vary continuously and regularly as the target identification detection signal and utilizes the static emission of Eu 3+ as the internal reference system. The change of fluorescence lifetime and quantum yield confirmed that this obvious visual optical color signal varying phenomenon can be ascribed to the internal energy-transfer process conversion caused by the unique host−quest interaction between methanol and Eu/Tb-G. In addition, the prepared Eu/Tb-G paper-based sensor has good stimulation response and recyclability to methanol vapor. The above discussion can establish Eu/Tb-G as a ratiometric and colorimetric fluorescent sensor for the detection of methanol and its vapor.

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“…Methanol vapor is commonly found in various industries including food processing, pharmaceuticals, water treatment, organic synthesis, automobile, and daily life, 13,14 but excess methanol vapor could affect the human circulatory system or central nervous system, leading to headache, loss of vision, and even possibility to death. 15 Considering redundant methanol vapor and environmental issues, making full use of methanol vapor into flexible sensors is necessary. Traditional methanol vapor sensors are mainly based on detecting resistance signals by ceramic materials such as ZnO or SnO 2 , which require high working temperature, limiting the practical application.…”

mentioning

confidence: 99%

Wearable Motion Smartsensors Self-Powered by Core–Shell Au@Pt Methanol Fuel Cells

Liu

Cheng

et al. 2021

ACS Sens.

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A wearable self-powered sensor is a promising frontier in recent flexible electronic devices. In this work, a wearable fuel cell (FC)-type self-powering motion smartsensor has been fabricated, particularly in choosing methanol vapor as a target fuel for the first time. The core–shell structure of Pt@Au/N-rGO and the porous carbon network act as methanol oxidation and oxygen reduction reaction catalysts, with a highly conductive alkaline hydrogel as a solid-state electrolyte. As a result, a wearable FC for a self-powered sensing system demonstrates excellent sensing performance toward 2–20% (v/v) methanol vapor with a maximum power density of 2.26 μW cm–1 and good mechanical behaviors during the bending or twisting process. Significantly, this wearable FC device could power strain sensors of human motion, and real-time signals can be easily remotely detected via a cellphone. With attractive biocompatibility and self-powering performance, wearable FCs for a self-powering system would provide new opportunities for next-generation flexible smartsensing electronics and initiate a developed self-powering platform in future practical application of wearable smart monitoring.

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NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of methanol

Cited by 30 publications

References 118 publications

Temporal and Spatial Evaluation of Mono(2-ethylhexyl) Phthalate (MEHP) Detection in Common Bottlenose Dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA

Temporal and Spatial Evaluation of Mono(2-ethylhexyl) Phthalate (MEHP) Detection in Common Bottlenose Dolphins (Tursiops truncatus) from Sarasota Bay, Florida, USA

Self-Assembly of Lanthanide-Based Metallogel Nanoplates into Microcubic Blocks as Self-Calibrating Luminescent Methanol Sensors

Wearable Motion Smartsensors Self-Powered by Core–Shell Au@Pt Methanol Fuel Cells

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