NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

,

doi:10.22427/ntp-tox-96

Cited by 10 publications

(6 citation statements)

References 63 publications

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“…In general, male rats appear more sensitive to PFAS-induced liver toxicity in comparison with females and show more severe liver pathology in comparison with females at equipotent doses. 94 , 97 , 99 , 100 These findings support the selection of male rat toxicity data for derivation of RPFs. The database may be found in Table S1.…”

Section: Methodssupporting

confidence: 58%

“…Figure 4 shows the modeled repeated-dose serum concentration of PFBS over time, plotted together with the mean measured serum concentrations shown in NTP 99 at day 28. In Table 3 the modeled and reported serum concentrations are listed, showing that the model is able to predict the measured concentrations after 4 wk (

) of daily exposure, with ratios ranging from 0.5 to 5.5.…”

Section: Resultsmentioning

confidence: 99%

“…For seven PFAS (PFHxA, PFOA, PFNA, PFDA, PFBS, PFHxS, PFOS), measured serum concentrations were available to verify the performance of the models to simulate the serum concentrations after repeated dosing. Verification was done by plotting modeled serum concentrations together with empirically obtained repeated-dose serum concentrations obtained after daily exposure for 28 d. 99 , 100 These serum concentration data were retrieved from the CEBS database as well. Furthermore, the ratio between the modeled and reported mean serum concentration at the end of the study was evaluated.…”

Section: Methodsmentioning

confidence: 99%

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Internal Relative Potency Factors for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring

Bil

Zeilmaker

Bokkers

2022

Environ Health Perspect

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Background: In human biomonitoring, blood is often used as a matrix to measure exposure to per- and polyfluoroalkyl substances (PFAS). Because the toxicokinetics of a substance (determining the steady-state blood concentration) may affect the toxic potency, the difference in toxicokinetics among PFAS has to be accounted for when blood concentrations are used in mixture risk assessment. Objectives: This research focuses on deriving relative potency factors (RPFs) at the blood serum level. These RPFs can be applied to PFAS concentrations in human blood, thereby facilitating mixture risk assessment with primary input from human biomonitoring studies. Methods: Toxicokinetic models are generated for 10 PFAS to estimate the internal exposure in the male rat at the blood serum level over time. By applying dose–response modeling, these internal exposures are used to derive quantitative internal RPFs based on liver effects. Results: Internal RPFs were successfully obtained for nine PFAS. Perfluorobutanoic acid (PFBA), perfluorohexanoic acid (PFHxA), perfluorononanoic acid (PFNA), perfluorododecanoic acid (PFDoDA), perfluorooctane sulfonic acid (PFOS), and hexafluoropropylene oxide-dimer acid (HFPO-DA, or GenX) were found to be more potent than perfluorooctanoic acid (PFOA) at the blood serum level in terms of relative liver weight increase, whereas perfluorobutane sulfonic acid (PFBS) and perfluorohexane sulfonic acid (PFHxS) were found to be less potent. The practical implementation of these internal RPFs is illustrated using the National Health and Nutrition Examination Survey (NHANES) biomonitoring data of 2017–2018. Discussion: It is recommended to assess the health risk resulting from exposure to PFAS as combined, aggregate exposure to the extent feasible. https://doi.org/10.1289/EHP10009

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Section: Methodssupporting

confidence: 58%

) of daily exposure, with ratios ranging from 0.5 to 5.5.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Internal Relative Potency Factors for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring

Bil

Zeilmaker

Bokkers

2022

Environ Health Perspect

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“…However, breaking a C-C bond is less effective than C-F bond cleavage, 16,17 since the former generates short-chain perfluoroalkyl substances that are still found to be toxic. 18,19 Thus, the primary challenge in the complete treatment of PFAScontaminated water is the efficient dissociation of the strong C-F bonds in these pollutants.…”

mentioning

confidence: 99%

Real-time degradation dynamics of hydrated per- and polyfluoroalkyl substances (PFASs) in the presence of excess electrons

Yamijala

Shinde

Wong

2020

Phys. Chem. Chem. Phys.

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“…The results showed that only the urinary concentration of 2,4-dichlorophenol was significantly correlated with the decline of olfactory identification, whereas the highly concerning bisphenol A and bisphenol S exerted no obvious negative effects . In a toxicity report undertaken by the NTP, perfluorobutanesulfonic acid (PFBS) and perfluorohexanesulfonate potassium salt (PFHxSK) caused degenerated OE in Sprague–Dawley rats at a lower concentration compared with the dose necessary to cause other pathological defects, such as necrosis in the liver and kidney, thymic atrophy, and hypocellularity in bone marrow . However, our knowledge on chemosensory toxicity of other emerging contaminants like phthalate and CPs is still blank.…”

Section: Environmental Pollutants That Can Induce Chemosensory Dysfun...mentioning

confidence: 99%

Chemosensory Dysfunction Induced by Environmental Pollutants and Its Potential As a Novel Neurotoxicological Indicator: A Review

Sheng

Jiang

et al. 2021

Environ. Sci. Technol.

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Air pollution composed of the complex interactions among particular matter, chemicals, and pathogens is an emerging and global environmental issue that closely correlates with a variety of diseases and adverse health effects, especially increasing incidences of neurodegenerative diseases. However, as one of the prevalent health outcomes of air pollution, chemosensory dysfunction has not attracted enough concern until recently. During the COVID-19 pandemic, multiple scientific studies emphasized the plausibly essential roles of the chemosensory system in the airborne transmission airway of viruses into the human body, which can also be utilized by pollutants. In this Review, in addition to summarizing current progress regarding the contributions of traditional air pollutants to chemosensory dysfunction, we highlight the roles of emerging contaminants. We not only sum up clarified mechanisms, such as inflammation and apoptosis but also discuss some not yet completely identified mechanisms, e.g., disruption of olfactory signal transduction. Although the existing evidence is not overwhelming, the chemosensory system is expected to be a useful indicator in neurotoxicology and neural diseases based on accumulating studies that continually excavate the deep link between chemosensory dysfunction and neurodegenerative diseases. Finally, we argue the importance of studies concerning chemosensory dysfunction in understanding the health effects of air pollution and provide comments for some future directions of relevant research.

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NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

Cited by 10 publications

References 63 publications

Internal Relative Potency Factors for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring

Internal Relative Potency Factors for the Risk Assessment of Mixtures of Per- and Polyfluoroalkyl Substances (PFAS) in Human Biomonitoring

Real-time degradation dynamics of hydrated per- and polyfluoroalkyl substances (PFASs) in the presence of excess electrons

Chemosensory Dysfunction Induced by Environmental Pollutants and Its Potential As a Novel Neurotoxicological Indicator: A Review

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