NUCB2/nesfatin-1 is associated with elevated scores of anxiety in female obese patients

Hofmann, Tobias; Stengel, Andreas; Ahnis, Anne; Buße, Petra; Elbelt, Ulf; Klapp, Burghard F.

doi:10.1016/j.psyneuen.2013.05.013

Cited by 62 publications

(51 citation statements)

References 47 publications

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“…Two further studies also reported significant positive correlations of NUCB2/nesfatin-1 levels with the severity of agoraphobia (Panic and Agoraphobia Scale) (Bez et al, 2010) and of obsessive-compulsive disorder symptoms (Yale-Brown Obsessive Compulsive Scale) (Bez et al, 2012) in men and women. In line with these data, we reported a strong positive correlation of NUCB2/nesfatin-1 with anxiety and also perceived stress and depressiveness in obese women (Hofmann et al, 2013). However, a study conducted in men reported reduced circulating NUCB2/nesfatin-1 levels in patients with generalized anxiety disorder (Gunay et al, 2012).…”

Section: Introductionsupporting

confidence: 82%

“…Long-term changes of body weight also impact on circulating NUCB2/nesfatin-1 with decreased levels observed in anorexia nervosa (Ogiso et al, 2011) and elevated levels in overweight and obese subjects (Ramanjaneya et al, 2010). However, the association of NUCB2/nesfatin-1 with body mass index (BMI) remains controversial as studies show positive (Ramanjaneya et al, 2010;Saldanha et al, 2012), negative (Tsuchiya et al, 2010;Basar et al, 2012;Abaci et al, 2013;Guo et al, 2014) or no correlation (Hofmann et al, 2013) in different patient populations. This may point towards other factors that influence circulating NUCB2/nesfatin-1 levels.…”

Section: Introductionmentioning

confidence: 99%

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Sex-specific regulation of NUCB2/nesfatin-1: Differential implication in anxiety in obese men and women

Hofmann

Elbelt

Ahnis

et al. 2015

Psychoneuroendocrinology

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Section: Introductionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Sex-specific regulation of NUCB2/nesfatin-1: Differential implication in anxiety in obese men and women

Hofmann

Elbelt

Ahnis

et al. 2015

Psychoneuroendocrinology

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“…Our findings suggest that fat distribution is more important than weight gain or central obesity. Although expression of nesfatin-1 seems to depend on sex and nesfatin levels are higher in males [24][25][26] , we could not find any difference between the sexes. This issue also needs thorough investigation.…”

Section: Discussioncontrasting

confidence: 79%

Is There a Relationship between Obstructive Sleep Apnea Syndrome Severity and Nesfatin-1?

et al. 2015

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Background: Obstructive sleep apnea syndrome (OSAS) and obesity frequently occur together. The relationship between increased appetite and obesity is well known; however, despite existing knowledge about the relationship between OSAS and obesity, it is not fully understood. Objectives: This study aimed to evaluate the relationship between OSAS and the appetite-suppressing hormone nesfatin-1 independent of body mass index (BMI). Methods: A total of 134 cases were included in the study; 102 with OSAS (OSAS group) and 32 healthy controls (control group). All cases underwent polysomnography, and nesfatin-1 levels were determined. Results: Nesfatin-1 levels were significantly lower in the OSAS group compared to the control group (3,776.5 ± 204.8 and 4,056.2 ± 101.5 pg/ml, respectively; p < 0.001). In addition, there was a statistically significant negative correlation between nesfatin-1 and the apnea hypopnea index (r = -0.543; p < 0.001). The statistically significant relationship persisted after adjusting for confounding intergroup factors such as age, gender and BMI (p < 0.001). In the OSAS group, there was a statistically significant correlation between nesfatin-1 and neck circumference (r = -0.304; p = 0.02) but not between nesfatin-1 and BMI and waist circumference. There was no statistically significant difference in nesfatin-1 levels between the sexes. Conclusion: OSAS patients have lower nesfatin-1 levels compared to controls, and a greater nesfatin-1 deficit corresponds to an increased severity of OSAS and an increased neck circumference. Replacement therapy may be a potential treatment for obese OSAS patients who have lower nesfatin-1 levels, which may have additional benefits through appetite suppression and weight loss.

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“…NUCB2/nesfatin-1 plasma levels of patients affected by major depressive disorders were higher than those in healthy subjects (Ari et al 2011). Moreover, a positive correlation was found between circulating NUCB2/nesfatin-1 levels and anxiety in women diagnosed with anorexia nervosa (Hofmann et al 2015a) or obesity (Hofmann et al 2013(Hofmann et al , 2015b, whereas this relationship was inversed in obese men (Hofmann et al 2015b). Intriguingly, drug-free suicide male victims displayed higher Nucb2 mRNA expression in the Edinger-Westphal nucleus than in controls, whereas levels were lower in female victims (Bloem et al 2012).…”

Section: :1mentioning

confidence: 98%

Nesfatin-1: functions and physiology of a novel regulatory peptide

Dore

Levata

Lehnert

et al. 2017

Journal of Endocrinology

118

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Nesfatin-1 was identified in 2006 as a potent anorexigenic peptide involved in the regulation of homeostatic feeding. It is processed from the precursor-peptide NEFA/ nucleobindin 2 (NUCB2), which is expressed both in the central nervous system as well as in the periphery, from where it can access the brain via non-saturable transmembrane diffusion. In hypothalamus and brainstem, nesfatin-1 recruits the oxytocin, the melancortin and other systems to relay its anorexigenic properties. NUCB2/nesfatin-1 peptide expression in reward-related areas suggests that nesfatin-1 might also be involved in hedonic feeding. Besides its initially discovered anorexigenic properties, over the last years, other important functions of nesfatin-1 have been discovered, many of them related to energy homeostasis, e.g. energy expenditure and glucose homeostasis. Nesfatin-1 is not only affecting these physiological processes but also the alterations of the metabolic state (e.g. fat mass, glycemic state) have an impact on the synthesis and release of NUCB2 and/or nesfatin-1. Furthermore, nesfatin-1 exerts pleiotropic actions at the level of cardiovascular and digestive systems, as well as plays a role in stress response, behavior, sleep and reproduction. Despite the recent advances in nesfatin-1 research, a putative receptor has not been identified and furthermore potentially distinct functions of nesfatin-1 and its precursor NUCB2 have not been dissected yet. To tackle these open questions will be the major objectives of future research to broaden our knowledge on NUCB2/nesfatin-1.

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NUCB2/nesfatin-1 is associated with elevated scores of anxiety in female obese patients

Cited by 62 publications

References 47 publications

Sex-specific regulation of NUCB2/nesfatin-1: Differential implication in anxiety in obese men and women

Sex-specific regulation of NUCB2/nesfatin-1: Differential implication in anxiety in obese men and women

Is There a Relationship between Obstructive Sleep Apnea Syndrome Severity and Nesfatin-1?

Nesfatin-1: functions and physiology of a novel regulatory peptide

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