Nuchal translucency measurements in consecutive normal pregnancies. Is there a predisposition to increased levels?

Abstract

The current results indicate a significant correlation of NT values in consecutive unaffected pregnancies. There also was a predisposition for a repeated isolated increased NT in subsequent pregnancies. Additional series and more information are needed before firm conclusions can be made.

Comparison of pregnancy outcome of euploid fetuses with increased nuchal translucency (NT) expressed in NT MoM or delta‐NT

“…However, the association of enlarged NT and various neurodevelopmental abnormalities or genetic syndromes may be of clinical value for couples at risk for specific inherited genetic syndromes in which definitive prenatal diagnosis is not yet available. At the same time, increased NT may on rare occasions be familial and exist without any associated pathology22, 23.…”

The clinical evaluation and pregnancy outcome of euploid fetuses with increased nuchal translucency

“…Spencer (63) studied a group of 149 pregnant women and found no correlation between fetal NT's from different pregnancies of the same parturient women. In contrast, we (64) and others (20) have came across and reported on a total of six cases in which there was such a correlation. The relative risk of an isolated NT ≥ 95th centile in the first pregnancy to be followed by a similar result in the subsequent one was 21 (95% CI 4.53–97.44) (63).…”

“…Furthermore, no increased incidence for some anomalies has been demonstrated to date in cases of increased NT thickness. At the same time, increased NT may on rare occasions be familial, without any associated pathology (20, 64).…”