Nuciferine alleviates acute alcohol-induced liver injury in mice: Roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf2/HO-1 cascade

Gao, Shu; Qiu, Yunhan; Jiang, Hao; Fu, Qian; Deng, Xukun

doi:10.1016/j.jff.2019.04.055

Cited by 26 publications

(11 citation statements)

References 47 publications

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“…The results reveal that nuciferine could activate Nrf2/heme oxygenase 1 (HO-1) signaling in HepG2 hepatocytes and protect against alcohol-induced ROS generation. Of note, nuciferine ameliorated alcohol-induced liver injury by activating miR-144/Nrf2/HO-1 pathway, alleviating OS, and reducing inflammation [ 116 ].…”

Section: Bioactive Compounds Ameliorate Ald Via Multiple Pathwaysmentioning

confidence: 99%

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

et al. 2021

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Alcoholic liver disease (ALD) is one type of liver disease, causing a global healthcare problem and mortality. The liver undergoes tissue damage by chronic alcohol consumption because it is the main site for metabolism of ethanol. Chronic alcohol exposure progresses from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which further lead to fibrosis, cirrhosis, and even hepatocellular cancer. Therapeutic interventions to combat ALD are very limited such as use of corticosteroids. However, these therapeutic drugs are not effective for long-term usage. Therefore, additional effective and safe therapies to cope with ALD are urgently needed. Previous studies confirmed that edible food plants and their bioactive compounds exert a protective effect against ALD. In this review article, we summarized the hepatoprotective potential of edible food plants and their bioactive compounds. The underlying mechanism for the prevention of ALD by edible food plants was as follows: anti-oxidation, anti-inflammation, lipid regulation, inhibition of apoptosis, gut microbiota composition modulation, and anti-fibrosis.

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Section: Bioactive Compounds Ameliorate Ald Via Multiple Pathwaysmentioning

confidence: 99%

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

et al. 2021

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“…17 Additionally, ROS serve as the important intracellular messengers to activate multiple signalling pathways, thereby indirectly inducing tissue and cell injury. 18 Free radicals and their induced OS run through various liver diseases, which is one of the main mechanisms leading to liver diseases. NF-κB is a kind of heterodimer constituted by p60 and p65 subunits, and it is the first transcription factor verified to directly respond to OS.…”

Section: Discussionmentioning

confidence: 99%

“…Under pathological condition, the ability to scavenge ROS in the body decreases, and the excessive production of free radicals will lead to OS, inducing lipid peroxidation of polyunsaturated fatty acid in the biomembrane phospholipid, intracellular protein and enzyme denaturation, and DNA oxidative damage 17 . Additionally, ROS serve as the important intracellular messengers to activate multiple signalling pathways, thereby indirectly inducing tissue and cell injury 18 . Free radicals and their induced OS run through various liver diseases, which is one of the main mechanisms leading to liver diseases.…”

Section: Discussionmentioning

confidence: 99%

Antrodia camphorata polysaccharide improves inflammatory response in liver injury via the ROS/TLR4/NF‐κB signal

Yang

Han

Sheng

et al. 2022

J Cellular Molecular Medi

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Antrodia Camphorata Polysaccharide (ACP) refers to a kind of polysaccharide extracted from the natural porous fungus Antrodia camphorata. This study investigated the mechanism of action of ACP in protecting the liver. The results showed that ACP suppressed the LPS‐induced KC cell activation, reduced the expression of inflammatory factors, increased the SOD level and suppressed ROS expression. In addition, N‐acetylcysteine (NAC) was adopted for pre‐treatment to suppress ROS. The results indicated that NAC synergistically exerted its effect with ACP, suggesting that ACP played its role through suppressing ROS. Further detection revealed that ACP activated the Nrf2 signal. It was discovered in the mouse model that, ACP effectively improved liver injury in mice, decreased ALT and AST levels, and suppressed the expression of inflammatory factors. This study suggests that ACP can exert its effect against oxidative stress via the Nrf2‐ARE signalling, which further improves the production of ROS and the activation of TLR4‐NF‐κB signalling, and protects the liver against liver injury.

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“…On the other hand, resveratrol repressed the hypoxia-induced resistance to doxorubicin in MCF-7 cells via downregulation of HIF-1α protein expression [208]. Nuciferine is an aromatic alkaloid extracted from lotus leaves that exhibited anti-inflammatory, antioxidant, and anticancer properties [209,233,234]. Recently, nuciferine has been applied in drug-resistant tumor cells, and it was able to regulate MDR proteins as well as reduce the activation of Nrf2 and HIF-1α [235].…”

Section: Hypoxia-inducible Factormentioning

confidence: 99%

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

et al. 2021

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Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural products as possible inhibitors for drug resistance in cancer. The molecular targets and the mechanisms of action of each natural product are also explained. Diverse drug resistance biomarkers were sensitive to natural products. P-glycoprotein and breast cancer resistance protein can be targeted by a large number of natural products. On the other hand, protein kinase C and topoisomerases were less sensitive to most of the studied natural products. The studies discussed in this review will provide a solid ground for scientists to explore the possible use of natural products in combination anticancer therapies to overcome drug resistance by targeting multiple drug resistance mechanisms.

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Nuciferine alleviates acute alcohol-induced liver injury in mice: Roles of suppressing hepatic oxidative stress and inflammation via modulating miR-144/Nrf2/HO-1 cascade

Cited by 26 publications

References 47 publications

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

Protective Mechanism of Edible Food Plants against Alcoholic Liver Disease with Special Mention to Polyphenolic Compounds

Antrodia camphorata polysaccharide improves inflammatory response in liver injury via the ROS/TLR4/NF‐κB signal

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

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