2018
DOI: 10.1111/bph.14482
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Nuciferine ameliorates hepatic steatosis in high‐fat diet/streptozocin‐induced diabetic mice through a PPARα/PPARγ coactivator‐1α pathway

Abstract: Nuciferine improved lipid profile and attenuated hepatic steatosis in HFD/STZ-induced diabetic mice by activating the PPARα/PGC1α pathway. Nuciferine may be a potentially important candidate in improving hepatic steatosis and the management of T2DM.

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Cited by 153 publications
(105 citation statements)
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“…For example, exposure of myotubes to palmitic acid leads to attenuated insulin signaling, but exposure to oleic acid does not cause these changes; in addition, co‐incubation of palmitic acid–exposed cells with a lower concentration of oleic acid reverses the effects of the latter . In our in vitro study, we used palmitate to induce insulin resistance, which is a classic insulin resistance model that has been used in many studies . Although we did not determine whether stearate and oleate have the same effects on mitochondria in our experiment, it would be interesting and worth further investigation.…”
Section: Discussionmentioning
confidence: 94%
“…For example, exposure of myotubes to palmitic acid leads to attenuated insulin signaling, but exposure to oleic acid does not cause these changes; in addition, co‐incubation of palmitic acid–exposed cells with a lower concentration of oleic acid reverses the effects of the latter . In our in vitro study, we used palmitate to induce insulin resistance, which is a classic insulin resistance model that has been used in many studies . Although we did not determine whether stearate and oleate have the same effects on mitochondria in our experiment, it would be interesting and worth further investigation.…”
Section: Discussionmentioning
confidence: 94%
“…To monitor the kidney and liver function, the concentrations of creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in plasma were determined using an Auto Chemistry Analyzer (Hitachi 7180, Tokyo, Japan) as described previously [16,17].…”
Section: Kidney and Liver Functionmentioning
confidence: 99%
“…[30,31]. The main pharmacological effects of nuciferine include hyperlipidemia amelioration, stimulation of insulin secretion and vasodilation, hypotension induction, and anti-hepatic steatosis activity [32,33,34,35]. However, the effect of lotus leaf on adipocyte differentiation and its action mechanism remain unclear.…”
Section: Introductionmentioning
confidence: 99%