Nuciferine improves high-fat diet-induced obesity <i>via</i> reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota

Fang, Zhiyuan; Gao, Xinxing; Yu, Hao; Zhu, Yiwei; Ouyang, Hui-Lin; Song, Yuxiang; Du, Xiliang; Wang, Zhe; Li, Xinwei; Liu, Guowen

doi:10.1039/d1fo00367d

Cited by 29 publications

(19 citation statements)

References 46 publications

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“…The imbalance of gut microbiota is closely related to the pathogenesis of metabolic diseases, including hyperlipidemia and obesity [135]. Studies have shown that nuciferine can regulate the composition and potential function of intestinal microflora and reduce intestinal permeability, which can prevent weight gain, decrease fat accumulation, and ameliorate lipid metabolism disorders [136,137]. In vitro, nuciferine can decrease the intracellular TG content and inhibit the proliferation, differentiation, lipid accumulation and adipogenesis of 3T3-L1 preadipocytes.…”

Section: Nelumbinis Folium (Heye)mentioning

confidence: 99%

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Chen

et al. 2022

Chin Med

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Dyslipidemia is an independent risk factor of cardiovascular diseases (CVDs), which lead to the high mortality, disability, and medical expenses in the worldwide. Based on the previous researches, the improvement of dyslipidemia could efficiently prevent the occurrence and progress of cardiovascular diseases. Medicinal and edible plants (MEPs) are the characteristics of Chinese medicine, and could be employed for the disease treatment and health care mostly due to their homology of medicine and food. Compared to the lipid-lowering drugs with many adverse effects, such as rhabdomyolysis and impaired liver function, MEPs exhibit the great potential in the treatment of dyslipidemia with high efficiency, good tolerance and commercial value. In this review, we would like to introduce 20 kinds of MEPs with lipid-lowering effect in the following aspects, including the source, function, active component, target and underlying mechanism, which may provide inspiration for the development of new prescription, functional food and complementary therapy for dyslipidemia.

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Section: Nelumbinis Folium (Heye)mentioning

confidence: 99%

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Chen

et al. 2022

Chin Med

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“…Roseburia produces SCFAs that are associated with obesity ( 60 ). Akkermansia is an anti-obesity bacterium that can improve intestinal barrier integrity ( 62 ). Lactobacillus , Eisenbergiella , and Alistipes are the main producers of SCFAs ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Regulatory Effect of Mung Bean Peptide on Prediabetic Mice Induced by High-Fat Diet

Tian

Zhang

et al. 2022

Front. Nutr.

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Dietary supplementation with mung bean peptides (MBPs) has several health benefits. However, the effect of MBPs on prediabetes and gut microbiota imbalance caused by a high-fat diet (HFD) has not been thoroughly studied. In this study, dietary supplementation with MBPs for 5 weeks significantly reduced HFD-induced body weight gain, hyperglycaemia, hyperlipidaemia, insulin resistance, inflammation, and oxidative stress and alleviated liver and kidney damage in mice. In addition, it significantly reversed the HFD-induced gut microbiota imbalance, increased the gut microbial diversity, and decreased the abundance of Firmicutes and Bacteroidetes in prediabetic mice. Furthermore, we identified Lachnospiraceae_NK4A136 and Lactobacillus as important eubacteria with the potential to alleviate the clinical symptoms of prediabetes. According to PICRUSt2 analysis, the changes in intestinal microflora induced by MBPs diet intervention may be related to the downregulation of expression of genes such as rocR, lysX1, and grdA and regulation of seven pathways, including pyruvate, succinic acid, and butyric acid. Moreover, 17 genera with significantly altered levels in the intestine of HFD-fed mice, including Akkermansia, Roseburia, and Ruminiclostridium, were significantly correlated with 26 important differential metabolites, such as D-glutathione, anti-oleic acid, and cucurbitacin. Overall, these results show that MBPs diet intervention plays a key role in the management of HFD-induced prediabetes.

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“…16S rRNA gene sequencing of fecal microbiota further shows that nuciferine also modulates gut microbiota dysbiosis and changes the diversity and composition of gut microbiota towards a healthy level in high-fat diet-fed rats [ 83 ]. The data from the composition of gut microbiota show that nuciferine significantly shifts microbial structure, which includes the reduction in the abundance of Butyricimonas and the enhancement of the abundance of Akkermansia, an anti-obesity bacterium in high-fat diet-fed animals [ 84 , 85 ]. These results indicate that gut microbiota may play an essential role in the anti-hyperlipidemic and liver steatosis-alleviating effects of nuciferine.…”

Section: Potent Restoration Of Intestinal Microbiota-mediated Metabolic Syndromementioning

confidence: 99%

“…Subsequently, in lipopolysaccharide-exposed Caco-2 and HT-29 cells, this compound promotes the formation of autophagosomes and autophagolysosomes and alleviates intestinal permeability reduction. Importantly, it protects against lipopolysaccharide-induced paracellular permeability impairment after the transfection of the autophagy-related gene ( Atg ) 5 siRNA, indicating that nuciferine improves autophagy with intestinal permeability [ 84 ]. On the other hand, metabolomic analysis further characterizes the effects of nuciferine for NAFLD at a metabolic level.…”

Section: Potent Restoration Of Intestinal Microbiota-mediated Metabolic Syndromementioning

confidence: 99%

Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome

et al. 2021

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The incidence and prevalence of metabolic syndrome has steadily increased worldwide. As a major risk factor for various diseases, metabolic syndrome has come into focus in recent years. Some natural aporphine alkaloids are very promising agents in the prevention and treatment of metabolic syndrome and its components because of their wide variety of biological activities. These natural aporphine alkaloids have protective effects on the different risk factors characterizing metabolic syndrome. In this review, we highlight the activities of bioactive aporphine alkaloids: thaliporphine, boldine, nuciferine, pronuciferine, roemerine, dicentrine, magnoflorine, anonaine, apomorphine, glaucine, predicentrine, isolaureline, xylopine, methylbulbocapnine, and crebanine. We particularly focused on their impact on metabolic syndrome and its components, including insulin resistance and type 2 diabetes mellitus, endothelial dysfunction, hypertension and cardiovascular disease, hyperlipidemia and obesity, non-alcoholic fatty liver disease, hyperuricemia and kidney damage, erectile dysfunction, central nervous system-related disorder, and intestinal microbiota dysbiosis. We also discussed the potential mechanisms of actions by aporphine alkaloids in metabolic syndrome.

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Nuciferine improves high-fat diet-induced obesity via reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota

Abstract: Nuciferine (NF) has received extensive attention for its medicinal value in the treatment of metabolic diseases, such as obesity, but the effects of NF on obesity-related intestinal permeability, autophagy and...

Cited by 29 publications

References 46 publications

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Medicinal and edible plants in the treatment of dyslipidemia: advances and prospects

Regulatory Effect of Mung Bean Peptide on Prediabetic Mice Induced by High-Fat Diet

Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome

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