2013
DOI: 10.1016/j.neuron.2012.10.037
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Nuclear Calcium Signaling in Spinal Neurons Drives a Genomic Program Required for Persistent Inflammatory Pain

Abstract: Summary Persistent pain induced by noxious stimuli is characterized by the transition from normosensitivity to hypersensitivity. Underlying mechanisms are not well understood, although gene expression is considered important. Here we show that persistent nociceptive-like activity triggers calcium transients in neuronal nuclei within the superficial spinal dorsal horn, and that nuclear calcium is necessary for the development of long-term inflammatory hypersensitivity. Using a nucleus-specific calcium signal pe… Show more

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Cited by 103 publications
(114 citation statements)
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“…Separate mouse cohorts consisted of at least 7 animals per DIA-MS replicate. All of them exhibited pronounced mechanical hypersensitivity as described previously (26,29) and shown in Fig. 1B.…”
Section: Methodssupporting
confidence: 79%
“…Separate mouse cohorts consisted of at least 7 animals per DIA-MS replicate. All of them exhibited pronounced mechanical hypersensitivity as described previously (26,29) and shown in Fig. 1B.…”
Section: Methodssupporting
confidence: 79%
“…pAAV-hrGFP, pAAV-mC.NLS, pAAV-shC1q-c, and pAAV-shUNC have been characterized previously (9,(11)(12)(13). For the construction of the nuclearly targeted parvalbumin expression vector, the PV.NLS coding sequence was PCR-amplified from pCMV-PV.NLSdsRed (14) and then subcloned into pAAV-mC to yield an inframe PV.NLS-mC fusion.…”
Section: Methodsmentioning
confidence: 99%
“…We focused on two nuclear calcium signaling targets, VEGFD and the complement factor C1q-c, that can function as regulators of neuronal structure (9,11). In the mouse hippocampus, VEGFD is critical for dendritic tree maintenance and is required for the ability of mice to form long-term memories (9).…”
Section: Pvnls Influences the Transcription Of Genes Important For Nmentioning
confidence: 99%
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