“…Importantly, deformation of the nucleus, whether by migration through small pores, direct application of force, or spreading on stiff substrates, has been implicated in the loss of nuclear repair factors and accumulation of DNA damage [ 71 , 72 , 73 , 74 ]. Though increased DNA damage from deformation has not yet been documented in primary liver cells, nuclear deformation is increased in chronic liver diseases, raising the possibility that deformation is a mechanism of oncogenesis [ 61 , 75 ].…”