Small modular reactors (SMRs) represent a key area of interest to nuclear industry developers, which have been making significant progress during the past few years. Generally, these reactors are promising owing to their improved safety due to passive systems, enhanced containment efficiency, and fewer capital costs in comparison to traditional nuclear reactors. An important advantage of SMRs is their adaptability in being coupled to other energy-consuming systems, such as desalination plants (DPs) to create a cogeneration plant. Considering the serious challenges regarding the freshwater shortage in many regions of the world and the necessity of using low-carbon energy sources, it is advantageous to use SMR for supplying the required heat and electricity of DPs. As a high-performance desalination technology, the hybrid desalination (HD) systems can be exploited, which retain the advantages of both thermal and membrane desalination methods. In this study, several SMR coupling schemes to HD plants have been suggested. In performing a thermodynamic analysis of integrated SMR-DP, the International Atomic Energy Agency (IAEA) Desalination Thermodynamic Optimization Program (DE-TOP) has been utilized. It has been found that the use of relatively hot water from the SMR condenser leads to about 6.5 to 7.5% of total desalination cost reduction, where the produced electricity and hot steam extracted from low-pressure turbine were used to drive the HD system.