2008
DOI: 10.2203/dose-response.08-024.cuttler
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Nuclear Energy and Health

Abstract: ᮀ Energy needs worldwide are expected to increase for the foreseeable future, but fuel supplies are limited. Nuclear reactors could supply much of the energy demand in a safe, sustainable manner were it not for fear of potential releases of radioactivity. Such releases would likely deliver a low dose or dose rate of radiation, within the range of naturally occurring radiation, to which life is already accustomed. The key areas of concern are discussed. Studies of actual health effects, especially thyroid cance… Show more

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Cited by 46 publications
(11 citation statements)
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“…Although a number of publications have assessed the hormesis concept and its toxicological, biomedical, and clinical implications (Arumugam, Gleichmann, Tang, & Mattson, 2006;Cuttler, 2007;Cuttler & Pollycove, 2009;Hoffmann, 2009;Scott, 2008), this is the first comprehensive assembly and analysis of the hormetic effects of curcumin and their potential clinical significance. The present analysis shows that curcumin acts in a hormetic-like manner in several biological models, affecting a plethora of endpoints of biomedical importance.…”
Section: Discussionmentioning
confidence: 99%
“…Although a number of publications have assessed the hormesis concept and its toxicological, biomedical, and clinical implications (Arumugam, Gleichmann, Tang, & Mattson, 2006;Cuttler, 2007;Cuttler & Pollycove, 2009;Hoffmann, 2009;Scott, 2008), this is the first comprehensive assembly and analysis of the hormetic effects of curcumin and their potential clinical significance. The present analysis shows that curcumin acts in a hormetic-like manner in several biological models, affecting a plethora of endpoints of biomedical importance.…”
Section: Discussionmentioning
confidence: 99%
“…However, huge doubts, in many scientific circles, are raised by the stimulation of the system with low doses of ionizing radiation. The reason may be the lack of a full evaluation of the phenomenon of radiation hormesis, which is considered a positive phenomenon causing the body's repair processes [27, 28]. Undoubtedly, there is no research in line with the principles of evidence-based medicine regarding radon spa therapy.…”
Section: Discussionmentioning
confidence: 99%
“…The COVID-19 Rapid Letter by Boon et al urged caution and careful examination of the evidence and logistics of low-dose radiotherapy in COVID-19 patients. 1 This is exactly what was requested in the March 20, 2020, Cuttler to Hahn letter to the FDA 2 and what has occurred since late April 2020 when the first phase I/II clinical trial was approved at the Winship Cancer Institute, Emory University Hospital. 3 The preprint of day-7 interim results by the investigators concluded, “In a small pilot trial of 5 oxygen-dependent patients with COVID-19 pneumonia, low-dose whole-lung radiation led to rapid improvement in clinical status, encephalopathy, and radiographic infiltrates without acute toxicity or worsening the cytokine storm.…”
mentioning
confidence: 64%