Nuclear expression of MATK is a novel marker of type II enteropathy-associated T-cell lymphoma

Sy, Tan; As, Ooi; Ang, M-K.; Koh, Maki; Jc, Wong; Dykema, Karl; Ngeow, Joanne; Loong, Susan; Gatter, Kevin C.; Tan, Lihua; Lc, Lim; Furge, Kyle A.; Tao, Meixia; St, Lim; Loong, Florence; Cheah, Pike See; Teh, Bin Tean

doi:10.1038/leu.2010.295

Cited by 60 publications

(37 citation statements)

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“…EBV-infected B-cells as a consequence of a reduction in immune surveillance in T-cell lymphomas may be encountered and occasionally may be sufficiently numerous as to create diagnostic confusion with extranodal NK/T-cell lymphoma. As we have previously reported, 18 high-level nuclear expression of MATK is a useful additional marker of Type II EATL to resolve diagnostic difficulties.…”

Section: Discussionmentioning

confidence: 80%

“…To gain a better understanding of the pathology of this neoplasm, we performed a larger study using MATK and other markers on cases contributed by multiple investigators in the Asia-Pacific region. A subset of these (cases 1-16, 20-33, 44-56) had been reported 12,17,18 in earlier studies.…”

Section: Introductionmentioning

confidence: 90%

“…A case was entered into the study if there was consensus between the contributing pathologist and the study pathologist. Forty-three cases had been reported in previous studies, including 13 from Taiwan, 11,17 Korea, 12,22 Singapore, 18 whereas five other cases were excluded because they were EBER-positive.…”

Section: Histology Review and Diagnostic Criteriamentioning

confidence: 99%

“…18 During screening of lymphoid neoplasms, we identified four older cases of 'EBV À (Epstein-Barr virus negative) natural killer (NK)/T-cell lymphoma' with high-level (470%) nuclear expression of MATK. This prompted histological review and subsequent re-classification as Type II EATL.…”

Section: Introductionmentioning

confidence: 99%

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Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype

et al. 2013

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In this multicentre study, we examined 60 cases of Type II enteropathy-associated T-cell lymphoma (EATL) from the Asia-Pacific region by histological review, immunohistochemistry and molecular techniques. Patients were mostly adult males (median age: 58 years, male:female 2.6:1), presenting with abdominal pain (60%), intestinal perforation (40%) and weight loss (28%). None had a history of coeliac disease and the median survival was only 7 months. Histologically, these tumours could be divided into (i) central tumour zone comprising a monotonous population of neoplastic lymphocytes, (ii) peripheral zone featuring stunted villi and morphologically atypical lymphocytes showing epitheliotropism, and (iii) distant mucosa with normal villous architecture and cytologically normal intra-epithelial lymphocytes (IELs). Characterized by extensive nuclear expression of Megakaryocyte-associated tyrosine kinase (MATK) (87%) and usually a CD8(+)CD56(+) (88%) cytotoxic phenotype, there was frequent aberrant expression of CD20 (24%). T-cell receptor (TCR) expression was silent or not evaluable in 40% but of the remainder, there was predominant expression of TCRαβ over TCRγδ (1.6:1). In keeping with the normal ratio of IEL subsets, CD8(+) cases showed predominant CD8αα homodimer expression (77%), regardless of TCR lineage. These tumours constitute a distinct entity from classical EATL, and the pathology may reflect tumour progression from IEL precursors, remnants of which are often seen in the distant mucosa.

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 90%

Section: Histology Review and Diagnostic Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype

et al. 2013

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“…Although EATL generally has a polymorphic cellular composition and wide range in cytology, MEITL is monomorphic, and usually positive for CD8, CD56, and MATK. 131 Gains in chromosome 8q24 involving MYC are seen in a high proportion of cases. 132 Many cases of MEITL are derived from gd T cells, but exceptions exist; some cases are T-cell receptor (TCR) silent and some cases express TCR ab.…”

Section: Org Frommentioning

confidence: 99%

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

Swerdlow

Campo

Pileri

et al. 2016

Blood

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A revision of the nearly 8-year-old World Health Organization classification of the lymphoid neoplasms and the accompanying monograph is being published. It reflects a consensus among hematopathologists, geneticists, and clinicians regarding both updates to current entities as well as the addition of a limited number of new provisional entities. The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies. The major changes are reviewed with an emphasis on the most important advances in our understanding that impact our diagnostic approach, clinical expectations, and therapeutic strategies for the lymphoid neoplasms.

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2021

Flow Cytometry of Hematological Malignancies

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Nuclear expression of MATK is a novel marker of type II enteropathy-associated T-cell lymphoma

Cited by 60 publications

References 4 publications

Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype

Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype

The 2016 revision of the World Health Organization classification of lymphoid neoplasms

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