2015
DOI: 10.1016/j.bbi.2015.07.014
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Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation

Abstract: Nuclear factor-kappa B (NF-κB) is a ubiquitously expressed protein complex regulating the transcription of genes involved in inflammation and pain. Increased NF-κB activity in immune and nervous system cells is linked to several chronic pain conditions in humans as well as inflammation- and nerve injury-evoked pain in animals. A recent in vitro study further demonstrates that increased NF-κB activity in astrocytes decreases transcription of catechol-o-methyltransferase (COMT), an enzyme that inactivates catech… Show more

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Cited by 83 publications
(50 citation statements)
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“…High concentrations of plasma BCAAs have been shown to increase oxidative stress and inflammation through the nuclear factor‐κB (NF‐κB) signaling pathway, which controls a number of pro‐inflammatory genes. Many of the pro‐inflammatory genes regulated by NF‐κB, such as tumor necrosis factor α, interleukin‐1β, and cyclooxygenase‐2 (COX‐2), play important roles in pain regulation . COX‐2 is an integral enzyme in the production of eicosanoids, which are themselves downstream products of PC metabolism due to the release of arachidonic acid, the precursor of eicosanoids, during the conversion of PC to lysoPC by phospholipase A 2 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…High concentrations of plasma BCAAs have been shown to increase oxidative stress and inflammation through the nuclear factor‐κB (NF‐κB) signaling pathway, which controls a number of pro‐inflammatory genes. Many of the pro‐inflammatory genes regulated by NF‐κB, such as tumor necrosis factor α, interleukin‐1β, and cyclooxygenase‐2 (COX‐2), play important roles in pain regulation . COX‐2 is an integral enzyme in the production of eicosanoids, which are themselves downstream products of PC metabolism due to the release of arachidonic acid, the precursor of eicosanoids, during the conversion of PC to lysoPC by phospholipase A 2 .…”
Section: Discussionmentioning
confidence: 99%
“…Many of the pro-inflammatory genes regulated by NF-κB, such as tumor necrosis factor α, interleukin-1β, and cyclooxygenase-2 (COX-2), play important roles in pain regulation. 40 COX-2 is an integral enzyme in the production of eicosanoids, 33 which are themselves downstream products of PC metabolism due to the release of arachidonic acid, the precursor of eicosanoids, during the conversion of PC to lysoPC by phospholipase A 2 . 41 Both NF-κB and COX-2 have been reported to be involved in OA; NF-κB signaling induces hypertrophy in chondrocytes, promotes synovitis and cartilage degradation, and alters resorption of bone, leading to abnormal bone formation.…”
Section: Journal Of Orthopaedic Researchmentioning
confidence: 99%
“…We explored the effects of p-CF 3 diEPP in the CFA test, composed of inactivated and dried Mycobacterium tuberculosis and adjuvant, a widely used model of persistent inflammatory pain. The CFA model is based on hypersensitivity, paw swelling, and nuclear factor-kB-mediated transcription of tumor necrosis factora involved in the formation of the principal mediators of inflammation (Hartung et al, 2015). Mice were injected intraplantarly with 20 ml of CFA (50%, diluted in mineral oil).…”
Section: In Vivo Methodsmentioning
confidence: 99%
“…Its target genes are still incompletely understood in the nervous system. Already known regulated genes in neuronal tissue make up inducible NO-synthase (iNOS), μ-opiod receptors, brainderived neurotrophic factor, calmodulin-dependent protein kinase II, and catechol-omethyltransferase (COMT) [46,47]. Previous studies show that increased NF-κB activity enhances transcription of genes that cause pain (e.g., iNOS) and decreases ones that ease pain (e.g., COMT).…”
Section: Discussionmentioning
confidence: 99%