Nuclear factor-κB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in rats

Immune responses to adeno-associated virus type 2 encoding channelrhodopsin-2 in a genetically blind rat model for gene therapy

“…34 We also demonstrated the potent expression of NF-kB p65 in the rAAV-ChR2V-injected retinas. These results are consistent with reports that constitutive NF-kB activity is the result of ongoing synaptic activity.…”

Tacrolimus (FK506) prevents early retinal neovascularization in streptozotocin-induced diabetic mice

“…The released soluble cytotoxins by activated microglia contribute to neuronal and vascular cell death and it is essential to the inflammatory processes in the early stages of diabetic retinopathy [31], and the role of NF-κB in the activation of the retinal microglia has been investigated [32]. Several studies indicated that FK506 inhibit the activation of NF-κB in various cells by different mechanisms.…”

Retinoic acid attenuates lipopolysaccharide-induced inflammatory responses by suppressing TLR4/NF-κB expression in rat mammary tissue

“…LPS transfers signals via toll-like receptor 4 (TLR4), which initiates systemic inflammation by producing inflammatory mediators such as inflammatory cytokines, adhesion molecules, chemokines, growth factors and cyclooxygenase [10,11]. Moreover, indications are that expression of these inflammatory mediators is controlled by nuclear factor kappa-B (NF-κB) [12,13]. Since overwhelming inflammatory responses are prominent features of mastitis and play a central role in the pathogenesis of tissue damage, TLR4/NF-κB signalling may be an attractive target to achieve suppression of infection-induced activation of leukocytes, endothelial and epithelial cells as a means to prevent tissue damage during the development of mastitis.…”