Nuclear Galectins: Functionally Redundant Components in Processing of Pre-mRNA.

Patterson, Ronald J.; Dagher, Sue F.; Vyakarnam, Anandita; Wang, John L.; 淳, 平林

doi:10.4052/tigg.9.77

Cited by 11 publications

(6 citation statements)

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“…Although galectins lack a typical secretion signal peptide, they are present not only in the cytosol and the nucleus, but also in the extracellular space 37,54,55 . From the cytosol, galectins can be targeted for secretion by non-classical mechanisms, possibly by direct translocation across the plasma membrane 55 (FIG.…”

Section: Galectins: Structure–function Relationshipsmentioning

confidence: 99%

Roles of galectins in infection

2009

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Galectins, which were first characterized in the mid-1970s, were assigned a role in the recognition of endogenous (‘self) carbohydrate ligands in embryogenesis, development and immune regulation. Recently, however, galectins have been shown to bind glycans on the surface of potentially pathogenic microorganisms, and function as recognition and effector factors in innate immunity. Some parasites subvert the recognition roles of the vector or host galectins to ensure successful attachment or invasion. This Review discusses the role of galectins in microbial infection, with particular emphasis on adaptations of pathogens to evasion or subversion of host galectin-mediated immune responses.

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Section: Galectins: Structure–function Relationshipsmentioning

confidence: 99%

Roles of galectins in infection

2009

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“…These proteins appeared to act at early stages in the splicing pathway, possibly those involved in the conversion of H complexes to commitment structures. 107 Elucidation of the nuclear ligands will be critical for the understanding of this first intracellular function for galectins. A short but deep traverse to the nucleus!…”

Section: Galectins In Multistep Tumor Spreading: Seeing the Woods Formentioning

confidence: 99%

Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy

1999

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Galectins constitute a family of evolutionarily conserved animal lectins, which are defined by their affinity for poly-Nacetyllactosamine-enriched glycoconjugates and sequence similarities in the carbohydrate recognition domain. During the past decade, attempts to dissect the functional role for galectins in vivo have been unsuccessful in comparison to the overwhelming information reached at the biochemical and molecular levels. The present review deals with the latest advances in galectin research and is aimed at validating the functional significance of these carbohydrate-binding proteins. Novel implications of galectins in cell adhesion, cell growth regulation, immunomodulation, apoptosis, inflammation, embryogenesis, metastasis and pre-mRNA splicing will be particularly discussed in a trip from the gene to the clinical therapy. Elucidation of the molecular mechanisms involved in galectin functions will certainly open new avenues not only in biomedical research, but also at the level of disease diagnosis and clinical intervention, attempting to delineate new therapeutic strategies in autoimmune diseases, inflammatory processes, allergic reactions and tumor spreading.

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“…2). From the cytosol, galectins may be targeted for secretion by non-classical mechanisms, possibly by direct translocation across the plasma membrane (Cho and Cummings 1995; Patterson et al 1997; Sato and Hughes 1994; Cleves et al 1996). …”

Section: Introductionmentioning

confidence: 99%

Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution

Vasta

2011

Advances in Experimental Medicine and Biology

216

177

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Galectins constitute an evolutionary conserved family of β-galactoside-binding proteins, ubiquitous in mammals and other vertebrate taxa, invertebrates, and fungi. Since their discovery in the 1970s, their biological roles, initially understood as limited to recognition of carbohydrate ligands in embryogenesis and development, have expanded in recent years by the discovery of their immunoregulatory activities. A gradual paradigm shift has taken place in the past few years through the recognition that galectins also bind glycans on the surface of potentially pathogenic microbes, and function as recognition and effector factors in innate immunity. Further, an additional level of functional complexity has emerged with the most recent findings that some parasites “subvert” the recognition roles of the vector/host galectins for successful attachment or invasion.

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Nuclear Galectins: Functionally Redundant Components in Processing of Pre-mRNA.

Cited by 11 publications

References 0 publications

Roles of galectins in infection

Roles of galectins in infection

Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy

Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution

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