Nuclear Imaging in Cardiovascular Medicine

Jain, Diwakar; Zaret, Barry L.

doi:10.1007/978-1-4614-6705-2_12

Cited by 3 publications

(3 citation statements)

References 94 publications

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“…Myocardial perfusion imaging (MPI) using radiotracers is a notable development in this field . Introduction of a new generation of radiotracers for MPI, agents for pharmacological stress test, and advances in gamma imaging cameras and image processing have resulted in its wide clinical acceptance . MPI has played an important role in large clinical trials, which resulted in the evolution of the current therapy of CAD .…”

Section: Introductionmentioning

confidence: 99%

“…Despite all of these strengths, MPI does suffer from several drawbacks. The sensitivity and specificity of MPI for the diagnosis of CAD are relatively suboptimal . Furthermore, the sensitivity of MPI for detecting individual coronary vessels with significant obstructive disease is quite low.…”

Section: Introductionmentioning

confidence: 99%

“…A wide variety of artifacts can also mimic cold‐spot abnormality. These drawbacks of MPI warrant consideration of alternative imaging modalities for detecting CAD …”

Section: Introductionmentioning

confidence: 99%

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Direct Myocardial Ischemia Imaging: a New Cardiovascular Nuclear Imaging Paradigm

Jain

Lele

et al. 2014

Clinical Cardiology

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Myocardial perfusion imaging (MPI), using radiotracers, has been in routine clinical use for over 40 years. This modality is used for the detection of coronary artery disease (CAD), risk stratification, optimizing therapy, and follow-up of patients with CAD. Molecular cardiovascular imaging using targeted radiotracers provides a unique opportunity for imaging biochemical and metabolic processes, and cell membrane transporter and receptor functions at a cellular and molecular level in experimental animal models as well as in humans. Cardiac imaging using radiolabeled free fatty acid analogues and glucose analogues enable us to image myocardial ischemia directly as an alternative to stress-rest MPI. Direct ischemia imaging techniques can avoid and overcome some of the limitations of standard stress-rest MPI. This article describes recent studies using 18 F-fluorodeoxyglucose ( 18 FDG) for myocardial ischemia imaging.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Direct Myocardial Ischemia Imaging: a New Cardiovascular Nuclear Imaging Paradigm

Jain

Lele

et al. 2014

Clinical Cardiology

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Chelation Therapy in the Treatment of Metal Intoxication

Aaseth¹,

Crisponi

Andersen³

2016

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Direct imaging of myocardial ischemia: A potential new paradigm in nuclear cardiovascular imaging

Jain

2008

Journal of Nuclear Cardiology

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Myocardial perfusion imaging has been in clinical use for over 30 years, serving as an effective, reliable, and relatively simple tool for diagnosis, risk stratification, and long-term follow-up of patients with suspected or known coronary artery disease. However, a unique strength of nuclear imaging is its ability to provide tools for imaging biochemical and metabolic processes and receptor and transporter functions at molecular and cellular levels in intact organisms under a wide variety of physiologic conditions. Despite their high resolution and technical sophistication, other imaging modalities currently do not have this capability. Metabolic imaging techniques using radiolabeled free fatty acid and glucose analogs provide a unique ability to image myocardial ischemia directly in patients with known or suspected coronary artery disease. These techniques can potentially overcome some of the limitations of currently used stress-rest perfusion imaging and also provide a unique opportunity to detect and image an episode of ischemia in the preceding hours even in the absence of other markers of ongoing myocardial ischemia. We describe recent studies using fluorine 18-labeled deoxyglucose and iodine 123 beta-methyl-p-iodophenyl-pentadecanoic acid for imaging myocardial ischemia.

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Nuclear Imaging in Cardiovascular Medicine

Cited by 3 publications

References 94 publications

Direct Myocardial Ischemia Imaging: a New Cardiovascular Nuclear Imaging Paradigm

Direct Myocardial Ischemia Imaging: a New Cardiovascular Nuclear Imaging Paradigm

Chelation Therapy in the Treatment of Metal Intoxication

Direct imaging of myocardial ischemia: A potential new paradigm in nuclear cardiovascular imaging

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