Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

Tay, Moon Y. F.; Fraser, Johanna E.; Chan, Wing Ki; Moreland, Nicole J.; Rathore, Abhay P. S.; Wang, Chieh-Huei; Vasudevan, Subhash G.; Jans, David A.

doi:10.1016/j.antiviral.2013.06.002

Cited by 287 publications

(277 citation statements)

References 32 publications

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“…In addition to this, ivermectin is also reported to interfere with DENV infectivity by blocking importin α/β-mediated nuclear localization of DENV RdRp [50]. A later study which observed ivermectinmediated inhibition of interaction of NS5 polymerases of both DENV-1 and DENV-2 with the nuclear import machinery, found the drug to be able to inhibit the replication of all four DENVs in infected cells in culture [51]. A phase II/III (NCT02045069) trial to test ivermectin's safety and efficacy in >350 dengue patients is underway in Thailand (Table 2).…”

Section: Ivermectinmentioning

confidence: 91%

Investigational drugs in early development for treating dengue infection

Beesetti

Khanna

Swaminathan

2016

Expert Opinion on Investigational Drugs

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None of the handful of drugs tested so far has yielded encouraging results. Early trial experience has served to emphasize the challenge of drug testing in the short therapeutic time window available, the need for tools to predict 'high-risk' patients early on and the limitations of the existing pre-clinical model systems. Significant investment of efforts and resources is a must before the availability of a safe, effective and inexpensive dengue drug becomes a reality. Currently, supportive fluid therapy remains the only option available for dengue treatment.

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Section: Ivermectinmentioning

confidence: 91%

Investigational drugs in early development for treating dengue infection

Beesetti

Khanna

Swaminathan

2016

Expert Opinion on Investigational Drugs

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“…97 Ivermectin inhibits dengue viruses and interrupts virus replication, bestowing protection against infection with all distinct virus serotypes, and has unexplored potential as a dengue antiviral. 98 Ivermectin has also been demonstrated to be a potent broadspectrum specific inhibitor of importin α/β-mediated nuclear transport and demonstrates antiviral activity against several RNA viruses by blocking the nuclear trafficking of viral proteins. It has been shown to have potent antiviral action against HIV-1 and dengue viruses, both of which are dependent on the importin protein superfamily for several key cellular processes.…”

Section: Asthmamentioning

confidence: 99%

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

2017

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Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo's prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated. Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

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“…Currently, prevention and control solely depends on effective vector control [83]. Ivermectin has been shown to be inhibitory towards dengue viruses and to interrupt virus replication, offering protection against infection with all distinct virus serotypes, with unexplored potential as a dengue antiviral [84].…”

Section: Antiviralmentioning

confidence: 99%