2001
DOI: 10.1038/ncb0901-802
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Nuclear localization of EGF receptor and its potential new role as a transcription factor

Abstract: Epidermal growth factor receptor (EGFR) has been detected in the nucleus in many tissues and cell lines. However, the potential functions of nuclear EGFR have largely been overlooked. Here we demonstrate that nuclear EGFR is strongly correlated with highly proliferating activities of tissues. When EGFR was fused to the GAL4 DNA-binding domain, we found that the carboxy terminus of EGFR contained a strong transactivation domain. Moreover, the receptor complex bound and activated AT-rich consensus-sequence-depen… Show more

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Cited by 965 publications
(1,097 citation statements)
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References 29 publications
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“…3. The functional significance of cell surface receptor nuclear translocation was exemplified by the recent studies including the interaction of nuclear EGFR with cyclin D1 promoter [11], the association of nuclear ErbB2 with COX-2 promoter [12], and the regulation of STAT5A by ErbB4 …”
Section: Discussionmentioning
confidence: 99%
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“…3. The functional significance of cell surface receptor nuclear translocation was exemplified by the recent studies including the interaction of nuclear EGFR with cyclin D1 promoter [11], the association of nuclear ErbB2 with COX-2 promoter [12], and the regulation of STAT5A by ErbB4 …”
Section: Discussionmentioning
confidence: 99%
“…The reported tyrosine kinase receptors include four members of ErbB family [11][12][13][14][15] and other tyrosine kinase receptors like VEGF receptor [16], FGF receptor [17,18] and NGF receptor [19]. However, the four members of ErbB family were translocated in the nucleus in different form.…”
Section: Introductionmentioning
confidence: 99%
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“…In mouse hepatocytes, almost all of the proTGFa-pos nuclei were also positive for erbb-1 (Schausberger et al, 2003). Moreover, several very recent papers suggest that the erbb receptors 1, 3 and 4 may bypass the protein phosphorylation cascades for transducing mitogenic stimuli (Lin et al, 2001;Ni et al, 2001;Offterdinger et al, 2002). Thus, there is considerable evidence of a direct action of growth factors/growth factor receptors from the EGF/erbbreceptor family in the nucleus (Wells and Marti, 2002).…”
mentioning
confidence: 97%