Nuclear magnetic resonance and thermal studies of drug doped dipalmitoyl phosphatidyl choline-H2O systems

Deniz, K. Usha; Parvathanathan, P. S.; Datta, Geeta; Khetrapal, C. L.; Ramanathan, K. V.; Suryaprakash, N.; Raghotama, S.

doi:10.1007/bf02703871

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…Considering the phosphatidylcholine (DPPC) structure as an example ( Figure 2 ). The peaks ranging from 1.1 ppm to 1.4 ppm corresponds to (-CH 2 -) n , (ω-1)CH 2 and (ω-2)CH 2 ; 0.7 ppm corresponds to terminal alkyl protons (ωCH 3 ); and 1.8–2.5 ppm covers protons at α/β positions next to carbonyl group 51 . The broad peak seen at 3.9–4.7 ppm encompasses the alpha protons from the amino acids 52 constituting the keratin in the toe shed.…”

Section: Resultsmentioning

confidence: 99%

NMR spectroscopy reveals the presence and association of lipids and keratin in adhesive gecko setae

Jain

Stark

Niewiarowski

et al. 2015

Sci Rep

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Lipid and protein aggregates are one of the fundamental materials of biological systems. Examples include cell membranes, insect cuticle, vertebrate epidermis, feathers, hair and adhesive structures known as ‘setae’ on gecko toes. Until recently gecko setae were assumed to be composed entirely of keratin, but analysis of footprints left behind by geckos walking on surfaces revealed that setae include various kinds of lipids. However, the arrangement and molecular-level behavior of lipids and keratin in the setae is still not known. In the present study we demonstrate, for the first time, the use of Nuclear Magnetic Resonance (NMR) spectroscopy techniques to confirm the presence of lipids and investigate their association with keratin in ‘pristine' sheds, or natural molts of the adhesive toe pad and non-adhesive regions of the skin. Analysis was also carried on the sheds after they were ‘delipidized’ to remove surface lipids. Our results show a distribution of similar lipids in both the skin and toe shed but with different dynamics at a molecular level. The present study can help us understand the gecko system both biologically and for design of synthetic adhesives, but the findings may be relevant to the characteristics of lipid-protein interactions in other biological systems.

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Section: Resultsmentioning

confidence: 99%

NMR spectroscopy reveals the presence and association of lipids and keratin in adhesive gecko setae

Jain

Stark

Niewiarowski

et al. 2015

Sci Rep

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“…1 b). Some sharp peaks, from 0.8 to 2.3 ppm, were ascribed to lipid compositions 43 , 44 . The lipid peaks were the most distinct in cat hairs and hardly observed in pig hairs (Fig.…”

Section: Resultsmentioning

confidence: 99%

Integrative measurement analysis via machine learning descriptor selection for investigating physical properties of biopolymers in hairs

Takamura

Tsukamoto

Sakata

et al. 2021

Sci Rep

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Integrative measurement analysis of complex subjects, such as polymers is a major challenge to obtain comprehensive understanding of the properties. In this study, we describe analytical strategies to extract and selectively associate compositional information measured by multiple analytical techniques, aiming to reveal their relationships with physical properties of biopolymers derived from hair. Hair samples were analyzed by multiple techniques, including solid-state nuclear magnetic resonance (NMR), time-domain NMR, Fourier transform infrared spectroscopy, and thermogravimetric and differential thermal analysis. The measured data were processed by different processing techniques, such as spectral differentiation and deconvolution, and then converted into a variety of “measurement descriptors” with different compositional information. The descriptors were associated with the mechanical properties of hair by constructing prediction models using machine learning algorithms. Herein, the stepwise model refinement via selection of adopted descriptors based on importance evaluation identified the most contributive descriptors, which provided an integrative interpretation about the compositional factors, such as α-helix keratins in cortex; and bounded water and thermal resistant components in cuticle. These results demonstrated the efficacy of the present strategy to generate and select descriptors from manifold measured data for investigating the nature of sophisticated subjects, such as hair.

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Influence of the leprosy drug, dapsone on the model membrane dipalmitoyl phosphatidylethanolamine

Panicker¹

2006

Thermochimica Acta

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Nuclear magnetic resonance and thermal studies of drug doped dipalmitoyl phosphatidyl choline-H2O systems

Cited by 6 publications

References 4 publications

NMR spectroscopy reveals the presence and association of lipids and keratin in adhesive gecko setae

NMR spectroscopy reveals the presence and association of lipids and keratin in adhesive gecko setae

Integrative measurement analysis via machine learning descriptor selection for investigating physical properties of biopolymers in hairs

Influence of the leprosy drug, dapsone on the model membrane dipalmitoyl phosphatidylethanolamine

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