Nuclear magnetic resonance of iron and copper disease states

Vm, Runge; Clanton, JA; Fw, Smith; Hutchison, J.M.S.; Mallard, J. R.; Cl, Partain; James, A. Everette

doi:10.2214/ajr.141.5.943

Cited by 49 publications

(13 citation statements)

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“…Similarly, in vitro experiments have demonstrated a concentrationdependent effect of (ferric) iron on the T1 and T2 relaxa tion times [10,12].…”

Section: Discussionmentioning

confidence: 87%

“…Preliminary experience has indicated that MRI is a valuable method of detecting storage of paramagnetic substances such as iron [6], A marked reduction of the signal intensity of the magnetic impulse is measured over areas of iron deposition [10,II], mainly caused by a shortening of the T2 relaxation time [9,II]. Similarly, in vitro experiments have demonstrated a concentrationdependent effect of (ferric) iron on the T1 and T2 relaxa tion times [10,12].…”

Section: Discussionmentioning

confidence: 99%

“…Preliminary re ports have indicated the usefulness of MRI in detecting iron storage in liver and bone marrow in both adult and pediatric patients with hematological disorders [9][10][11][12][13]. In patients with a need for frequent blood transfusions and suspected iron overload, MRI is potentially suitable for monitoring progression of iron storage and/or response to chelation therapy.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic Resonance Imaging of Iron Overload in Children Treated with Peritoneal Dialysis

Querfeld

Dietrich

Taira

et al. 1988

Nephron

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The ability of magnetic resonance imaging (MRI) to detect iron overload in children with end-stage renal disease (ESRD) was studied in 18 multiply transfused patients, aged 15.5 ± 4.8 years, and 5 nontransfused children without evidence of renal disease. In the transfused patients, the serum ferritin (SF) level was compared to (a) a subjective rating of signal intensity of MRI images (scale of 0–10), (b) mean Tl values of liver and spleen, and (c) computer-assisted measurements of spin echo intensity (SEI) of liver, spleen, muscle and fat tissue. On subjective evaluation, the mean signal intensity was significantly lower in transfused patients than in controls and a significant correlation with the SF levels was observed for ratings of both liver and spleen. Mean Tl values of liver and spleen did not correlate with the SF levels. On computer analysis, the ratios of SEI of fat/liver, fat/spleen, muscle/liver and muscle/spleen were significantly correlated with the SF levels as well as the subjective evaluation sorces. These data indicate that MRI is a suitable technique of documenting the presence and degree of iron overload in multiply transfused children with ESRD.

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“…Similarly, in vitro experiments have demonstrated a concentrationdependent effect of (ferric) iron on the T1 and T2 relaxa tion times [10,12].…”

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic Resonance Imaging of Iron Overload in Children Treated with Peritoneal Dialysis

Querfeld

Dietrich

Taira

et al. 1988

Nephron

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“…In vitro studies have demonstrated that an increase in ferric iron concentration causes the T 1 [12] and T2 relaxation times [14] to decrease. Ferritin, and in particular its iron core, decreases the T2 relaxation time but not to the same extent as seen in hemosiderosis.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have documented diminished hepatic signal intensity as a very specific sign of hemosiderosis [9][10][11][12][13][14][15][16][17][18][19]. This prompted us to evaluate by MR a group of renal transplant patients to determine the presence of excess iron deposition and correlate the hemosiderosis with the number of transplants, years of hemodialysis and chronic renal failure, histocompatibility alleles (HLA) [20], and the number of blood transfusions.…”

mentioning

confidence: 99%

MRI of hepatic iron deposition in patients with renal transplant

Miller

Fisher

Soper

et al. 1991

Gastrointest Radiol

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Excess hepatic iron deposition was found in five of 15 (33%) renal transplant patients undergoing magnetic resonance (MR) screening for avascular necrosis of the femoral heads. Only one of these patients had overt liver disease. The number of prior blood transfusions was a significant factor for this deposition, whereas the age and sex of the patients, number and type of transplants, histocompatibility alleles (HLA), and years of hemodialysis and of chronic renal failure were not significant etiological factors. Liver/fat intensity ratios of less than 0.29 on T1-weighted images and ratios of less than 0.21 on T2-weighted images and a calculated T2 value of less than 35 ms were the best indicators of iron overload. Renal transplant patients are at great risk for excess hepatic iron deposition and MR imaging is a promising tool for the diagnosis of iron overload in this patient population.

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Clinical Assessment of 31 Patients With Wilson's Disease

Starosta-Rubinstein¹

1987

Arch Neurol

235

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Nuclear magnetic resonance of iron and copper disease states

Cited by 49 publications

References 1 publication

Magnetic Resonance Imaging of Iron Overload in Children Treated with Peritoneal Dialysis

Magnetic Resonance Imaging of Iron Overload in Children Treated with Peritoneal Dialysis

MRI of hepatic iron deposition in patients with renal transplant

Clinical Assessment of 31 Patients With Wilson's Disease

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