Nuclear magnetic resonance of laser-polarized noble gases in molecules, materials and organisms

Goodson, Boyd M.

doi:10.2172/753892

Cited by 31 publications

(60 citation statements)

References 46 publications

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“…Following initial studies of xenon in porous solids (1) xenon NMR spectroscopy has become a promising technique for probing molecular structure and dynamics in materials, liquids, and molecules in solution (2)(3)(4)(5). The magnetic resonance properties of 129 Xe are extremely sensitive to its local chemical environment and large 129 Xe NMR signals are readily attainable through the use of established optical pumping techniques (6).…”

Section: Introductionmentioning

confidence: 99%

“…The large range of 129 Xe chemical shifts (over 5000 ppm) is due to the polarizability of its large electron cloud which shields the nucleus from the surrounding magnetic field (2)(3)(4)(5). In the gas phase, interatomic collisions distort the xenon electron cloud so that the nucleus becomes deshielded and the 129 Xe resonance frequency shifts downfield continuously with increased gas density (14); for clusters of xenon gas trapped in porous solids, this downfield shift is discrete and depends on cluster size (15).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characterization of the Effects of Nonspecific Xenon–Protein Interactions on 129Xe Chemical Shifts in Aqueous Solution: Further Development of Xenon as a Biomolecular Probe

Rubin

Spence

Pines

et al. 2001

Journal of Magnetic Resonance

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of the Effects of Nonspecific Xenon–Protein Interactions on 129Xe Chemical Shifts in Aqueous Solution: Further Development of Xenon as a Biomolecular Probe

Rubin

Spence

Pines

et al. 2001

Journal of Magnetic Resonance

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“…Derzeit werden zwei verschiedene Techniken zur Polarisation von 3 HeGas angewendet: optisches Pumpen mittels des Spinaustauschverfahrens [12] und mittels des Metastabilitätsaus-tausches [13]. Bei ersterem Verfahren [17][18][19].…”

Section: Polarisationstechnikunclassified

Funktionelle MRT der Lunge unter Verwendung von hyperpolarisiertem 3Helium-Gas

Gast

Morbach²,

Kauczor

et al. 2005

Med Klin

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Lung imaging is traditionally done using X-ray-based methods, since MRI is limited by low proton density as well as inherent magnetic field inhomogeneities of the lung tissue. After introduction of MRI using hyperpolarized noble gases, a totally new field of MRI of the chest has rapidly evolved. These techniques reveal new functional information of the lungs, which could not be obtained before. The first part of this review describes the underlying MR technology explaining distribution of static ventilation, dynamic distribution of ventilation, lung microstructure (apparent diffusion coefficient [ADC]), measurement of oxygen partial pressure (pO(2)), and safety. The clinical potential is afterwards demonstrated in the second part. Therefore, the effort in normal lungs and the mainly focused diseases chronic obstructive pulmonary disease (COPD), smoker's lung, cystic fibrosis, asthma, lung transplantation, and pulmonary embolism are reported.

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“…Xenon has been used to study large area surfaces for quite some time [1][2][3][4][5]. The high sensibility of 129 Xe towards its physical environment, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…its large chemical shift range in physisorption, makes it especially suited for this task. The sensitivity of the NMR studies has been greatly increased by using laser-polarized, so called hyperpolarized, 129 Xe [5]. Smaller area substrates, diluted systems as dissolved Xe or gas filled volumes as in the lung became accessible to 129 Xe-NMR.…”

Section: Introductionmentioning

confidence: 99%