Nuclear magnetic resonance spectroscopy: A review of neuropsychiatric applications

Passe, Theodore J.; Charles, H. Cecil; Rajagopalan, Pradeep; Krishnan, K. Ranga Rama

doi:10.1016/0278-5846(95)00101-z

Cited by 38 publications

(37 citation statements)

References 104 publications

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“…7,8,11 In any case, whereas 31 P measures the levels of the phospholipid precursors (phosphomonoesters) and the phospholipid breakdown products (phosphodiesters), as well as high-energy phosphate metabolism, 1 H-MR spectroscopy measures the levels NAA and Cho. 3 Thus, these 2 MR spectroscopy techniques do not necessarily measure the same variables, making studies conducted by using differing techniques difficult to compare.…”

Section: Discussionmentioning

confidence: 99%

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Proton MR Spectroscopy: Higher Right Anterior Cingulate N-Acetylaspartate/Choline Ratio in Asperger Syndrome Compared with Healthy Controls

Öner¹,

Devrimci-Özgüven²,

Öktem³

et al. 2007

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 99%

“…3 To date, there has been only been 1 previously published MR spectroscopy study involving patients with AS. 4 In the study by Murphy et al, 4 1 H-MR spectroscopy was used to compare the prefrontal and parietal N-acetylaspartate (NAA), choline (Cho), creatine (Cr), and phosphocreatine levels in 14 patients with AS with those of 18 healthy controls.…”

mentioning

confidence: 99%

Proton MR Spectroscopy: Higher Right Anterior Cingulate N-Acetylaspartate/Choline Ratio in Asperger Syndrome Compared with Healthy Controls

Öner¹,

Devrimci-Özgüven²,

Öktem³

et al. 2007

American Journal of Neuroradiology

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“…We suggest that the abnormalities in the concentration of Cho might be caused by a preclinical abnormality in the metabolism of the neural cell membrane [40] . In addition, the abnormal values seem to correlate with a low score in face recognition tests [7] .…”

Section: Cholinementioning

confidence: 99%

Proton Spectroscopy in Alzheimer’s Disease and Cognitive Impairment No Dementia: A Community-Based Study

Azevedo

Tatsch²,

Hototian³

et al. 2008

Dement Geriatr Cogn Disord

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Objective: To describe the findings of proton magnetic resonance spectroscopy (¹H-MRS) in Alzheimer’s disease (AD) and cognitive impairment, no dementia (CIND) elderly from a community-based sample. Methods: Thirteen patients with AD, 12 with CIND and 15 normal individuals were evaluated. The ¹H-MRS was performed in the right temporal, left parietal and medial occipital regions studying the metabolites N-acetylaspartate (NAA), creatine (Cr), choline (Cho) and myoinositol (mI). The clinical diagnosis was based on standardized cognitive tests – MMSE and CAMDEX – and the results correlated with the ¹H-MRS. Results: Parietal Cho was higher in control individuals and lower in CIND subjects. AD and control groups were better identified by temporal and parietal mI combined with the temporal NAA/Cr ratio. CIND was better identified by parietal Cho. Conclusion: The ¹H-MRS findings confirmed the hypothesis that metabolic alterations are present since the first symptoms of cognitively impaired elderly subjects. These results suggest that combining MRS from different cerebral regions can help in the diagnosis and follow-up of community elderly individuals with memory complaints and AD.

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“…19 F NMR has been used since the eighties for in vivo studies. In the past, various reviewers have discussed diverse applications of in vivo 19 F NMR [21,27,28,[33][34][35][36][37][38][39][40][41]. Thomas [33], Selinsky and Burt [34], Prior et al [35] and London [36] reviewed the contemporary state-of-the-art, covering the entire spectrum of in vivo applications.…”

Section: Introductionmentioning

confidence: 99%

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

229

185

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The fluorine atom provides an exciting tool for diverse spectroscopic and imaging applications using Magnetic Resonance. The organic chemistry of fluorine is widely established and it can provide a stable moiety for interrogating many aspects of physiology and pharmacology in vivo. Strong NMR signal, minimal background signal and exquisite sensitivity to changes in the microenvironment have been exploited to design and apply diverse reporter molecules. Classes of agents are presented to investigate gene activity, pH, metal ion concentrations (e.g., Ca(2+), Mg(2+), Na(+)), oxygen tension, hypoxia, vascular flow and vascular volume. In addition to interrogating speciality reporter molecules, (19)F NMR may be used to trace the fate of fluorinated drugs, such as chemotherapeutics (e.g., 5-fluorouracil, gemcitabine), anesthetics (e.g., isoflurane, methoxyflurane) and neuroleptics. NMR can provide useful information through multiple parameters, including chemical shift, scalar coupling, chemical exchange and relaxation processes (R1 and R2). Indeed, the large chemical shift range (approximately 300 ppm) can allow multiple agents to be examined, simultaneously, using NMR spectroscopy or chemical shift selective imaging.

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Nuclear magnetic resonance spectroscopy: A review of neuropsychiatric applications

Cited by 38 publications

References 104 publications

Proton MR Spectroscopy: Higher Right Anterior Cingulate N-Acetylaspartate/Choline Ratio in Asperger Syndrome Compared with Healthy Controls

Proton MR Spectroscopy: Higher Right Anterior Cingulate N-Acetylaspartate/Choline Ratio in Asperger Syndrome Compared with Healthy Controls

Proton Spectroscopy in Alzheimer’s Disease and Cognitive Impairment No Dementia: A Community-Based Study

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

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