Nuclear Medicine Imaging of Infection/Inflammation by PET/CT and PET/MR

Amorim, Bárbara Juarez; Schaarschmidt, Benedikt Michael; Grueneisen, Johannes; Tajmir, Shahein; Umutlu, Lale; Signore, Alberto; Catalano, Onofrio A.

doi:10.1007/978-3-030-25494-0_14

Cited by 1 publication

(1 citation statement)

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“…Threedimensional models are increasingly being used in radiopharmaceutical research. The primary goal is to characterize novel radiotracers in vitro for nuclear medical imaging using single photon emission computed tomography (SPECT) or positron emission tomography (PET) [47][48][49][50][51][52][53]. Furthermore, 3D models can be used to design targeted nuclear medicine therapy (e.g., effects of α or β labelled radiopharmaceuticals).…”

Section: Nuclear Medicine Therapymentioning

confidence: 99%

Three-Dimensional In Vitro Tumor Spheroid Models for Evaluation of Anticancer Therapy: Recent Updates

Nayak,

Bentivoglio,

Varani

et al. 2023

Cancers

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Advanced tissue engineering processes and regenerative medicine provide modern strategies for fabricating 3D spheroids. Several different 3D cancer models are being developed to study a variety of cancers. Three-dimensional spheroids can correctly replicate some features of solid tumors (such as the secretion of soluble mediators, drug resistance mechanisms, gene expression patterns and physiological responses) better than 2D cell cultures or animal models. Tumor spheroids are also helpful for precisely reproducing the three-dimensional organization and microenvironmental factors of tumors. Because of these unique properties, the potential of 3D cell aggregates has been emphasized, and they have been utilized in in vitro models for the detection of novel anticancer drugs. This review discusses applications of 3D spheroid models in nuclear medicine for diagnosis and therapy, immunotherapy, and stem cell and photodynamic therapy and also discusses the establishment of the anticancer activity of nanocarriers.

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