Nuclear Medicine Imaging Procedures in Oncology

Mohan, Ajay-Mohan; Beindorff, Nicola; Brenner, Winfried

doi:10.1007/978-1-0716-1350-4_21

Methods in Molecular Biology

2021

DOI: 10.1007/978-1-0716-1350-4_21

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Nuclear Medicine Imaging Procedures in Oncology

Ajay-Mohan Mohan

Nicola Beindorff

Winfried Brenner

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Cited by 3 publications

References 43 publications

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A Survey of Crystals for SPECT Imaging

Xu,

Yan,

Wei

2024

Crystals

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Single-photon emission computed tomography (SPECT) is an important nuclear medicine imaging tool for diagnosis and drug research. The gamma-ray detector is the core component of the SPECT system and influences the overall system performance. The detector crystals, which can be divided into scintillation crystals and semiconductor crystals, are among the main determinants of the detector’s performance. The development of these crystal materials plays an important role in improving SPECT imaging. This paper provides a survey of the technological development and applications of several crystals currently used in SPECT detectors. Furthermore, it explores future research directions for the development of detector crystals.

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A Survey of Crystals for SPECT Imaging

Xu,

Yan,

Wei

2024

Crystals

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Non-Invasive In Vivo Bioimaging in Pigs

Abe,

Endo,

Hanazono

et al. 2024

IJTM

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Imaging technologies are used to observe the morphology and function of various organs in the body and have become indispensable in a multitude of fields, ranging from basic research to clinical medicine. The luminescence technology based on the luciferin–luciferase reaction has been used in many research fields as an imaging technique, enabling quantitative analysis and detection at high sensitivity. Specifically in gene therapy and cell therapy, it has been developed as an in vivo bioimaging technique mainly for small animal models because of its non-invasive and time-sequential analysis. Currently, translational research using this luminescence imaging technology in pigs for clinical applications is ongoing. In this review, we discuss the progress of these technologies and issues for their clinical application, focusing on pigs, by comparing conventional imaging techniques, including fluorescent probes, with luminescence imaging techniques.

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Evaluating the Sorption Affinity of Low Specific Activity 99Mo on Different Metal Oxide Nanoparticles

et al. 2022

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99Mo/99mTc generators are mainly produced from 99Mo of high specific activity generated from the fission of 235U. Such a method raises proliferation concerns. Alternative methods suggested the use of low specific activity (LSA) 99Mo to produce 99mTc generators. However, its applicability is limited due to the low adsorptive capacity of conventional adsorbent materials. This study attempts to investigate the effectiveness of some commercial metal oxides nanoparticles as adsorbents for LSA 99Mo. In a batch equilibration system, we studied the influence of solution pH (from 1–8), contact time, initial Mo concentration (from 50–500 mg∙L−1), and temperature (from 298–333 K). Moreover, equilibrium isotherms and thermodynamic parameters (changes in free energy ΔG0, enthalpy change ΔH0, and entropy ΔS0) were evaluated. The results showed that the optimum pH of adsorption ranges between 2 and 4, and that the equilibrium was attained within the first two minutes. In addition, the adsorption data fit well with the Freundlich isotherm model. The thermodynamic parameters prove that the adsorption of molybdate ions is spontaneous. Furthermore, some investigated adsorbents showed maximum adsorption capacity ranging from 40 ± 2 to 73 ± 1 mg Mo∙g−1. Therefore, this work demonstrates that the materials used exhibit rapid adsorption reactions with LSA 99Mo and higher capacity than conventional alumina (2–20 mg Mo∙g−1).

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Nuclear Medicine Imaging Procedures in Oncology

Cited by 3 publications

References 43 publications

A Survey of Crystals for SPECT Imaging

A Survey of Crystals for SPECT Imaging

Non-Invasive In Vivo Bioimaging in Pigs

Evaluating the Sorption Affinity of Low Specific Activity 99Mo on Different Metal Oxide Nanoparticles

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