Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication

Sankovski, Eve; Abroi, Aare; Ustav, Mart

doi:10.1016/j.virol.2017.11.013

Cited by 10 publications

(14 citation statements)

References 74 publications

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“…The E2-NMI complex also interacts with Brd4 (Sankovski et al, 2018), another protein involved in chromatin remodelling (Devaiah et al, 2016). Upon addition of ATP, the E2-NMI complex falls apart owing to a conformational change in NMI (Sankovski et al, 2018). This conformational change in NMI occurs within the motor domain, from which actin is released upon the binding of ATP; as proposed by the authors, this experiment thus suggests that actin may also be part of this NMI-E2 complex (Sankovski et al, 2018).…”

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 56%

“…As discussed above, the NMI-WSTF-SNF2h complex allows for viable RNAPI transcription , which the viral protein E2 hijacks for viral transcription (Sankovski et al, 2018). The E2-NMI complex also interacts with Brd4 (Sankovski et al, 2018), another protein involved in chromatin remodelling (Devaiah et al, 2016). Upon addition of ATP, the E2-NMI complex falls apart owing to a conformational change in NMI (Sankovski et al, 2018).…”

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 98%

“…The E2-NMI complex has been shown to actively remodel chromatin through interactions with the WSTF-SNF2h chromatin remodelling complex (Sankovski et al, 2018). As discussed above, the NMI-WSTF-SNF2h complex allows for viable RNAPI transcription , which the viral protein E2 hijacks for viral transcription (Sankovski et al, 2018).…”

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 99%

“…Viral genomes have to be maintained within the host cell nucleus, and their replication and expression needs to be regulated. NMI has been linked to these processes, although through roles that have already been described for transcription (Fuchsova et al, 2015;Sankovski et al, 2018;Oswald et al, 2017). The human papilloma virus has multiple E proteins that have a role in aiding viral infection proliferation (reviewed in Mattoscio et al, 2018).…”

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 99%

“…The human papilloma virus has multiple E proteins that have a role in aiding viral infection proliferation (reviewed in Mattoscio et al, 2018). So far, three E proteins have been found to be capable of interacting with NMI, namely E2 (Sankovski et al, 2018), E6 and E7 (Oswald et al, 2017).…”

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 99%

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Nuclear myosins – roles for molecular transporters and anchors

Cook

Gough

Toseland

2020

Journal of Cell Science

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The myosin family of molecular motors are well-characterised cytoskeletal proteins. However, myosins are also present in the nucleus, where they have been shown to have roles in transcription, DNA repair and viral infections. Despite their involvement in these fundamental cellular processes, our understanding of these functions and their regulation remains limited. Recently, research on nuclear myosins has been gathering pace, and this Review will evaluate the current state of the field. Here, we will focus on the variation in structure of nuclear myosins, their nuclear import and their roles within transcription, DNA damage, chromatin organisation and viral infections. We will also consider both the biochemical and biophysical properties and restraints that are placed on these multifunctional motors, and how they link to their cytoplasmic counterparts. By highlighting these properties and processes, we show just how integral nuclear myosins are for cellular survival.

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Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 56%

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 98%

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 99%

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 99%

Section: Involvement Of Nuclear Myosins In Viral Infectionsmentioning

confidence: 99%

See 3 more Smart Citations

Nuclear myosins – roles for molecular transporters and anchors

Cook

Gough

Toseland

2020

Journal of Cell Science

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Myosin motors on the pathway of viral infections

2022

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Molecular motors are microscopic machines that use energy from adenosine triphosphate (ATP) hydrolysis to generate movement. While kinesins and dynein are molecular motors associated with microtubule tracks, myosins bind to and move on actin filaments. Mammalian cells express several myosin motors. They power cellular processes such as endo‐ and exocytosis, intracellular trafficking, transcription, migration, and cytokinesis. As viruses navigate through cells, they may take advantage or be hindered by host components and machinery, including the cytoskeleton. This review delves into myosins' cell roles and compares them to their reported functions in viral infections. In most cases, the previously described myosin functions align with their reported role in viral infections, although not in all cases. This opens the possibility that knowledge obtained from studying myosins in viral infections might shed light on new physiological roles for myosins in cells. However, given the high number of myosins expressed and the variety of viruses investigated in the different studies, it is challenging to infer whether the interactions found are specific to a single virus or can be applied to other viruses with the same characteristics. We conclude that the participation of myosins in viral cycles is still a largely unexplored area, especially concerning unconventional myosins.

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Viruses and phospholipids: Friends and foes during infection

Rattay

Hufbauer

Hoboth

et al. 2023

Journal of Medical Virology

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Viruses have evolved complex and dynamic interactions with their host cells to enable viral replication. In recent years, insights have been gained into the increasingly important role of the host cell lipidome in the life cycle of several viruses. In particular, viruses target phospholipid signaling, synthesis, and metabolism to remodel their host cells into an optimal environment for their replication cycle. Conversely, phospholipids and their associated regulatory enzymes can interfere with viral infection or replication. This review highlights examples of different viruses that illustrate the importance of these diverse virus–phospholipid interactions in different cellular compartments, particularly the role of nuclear phospholipids and their association with human papillomavirus (HPV)‐mediated cancer development.

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Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication

Cited by 10 publications

References 74 publications

Nuclear myosins – roles for molecular transporters and anchors

Nuclear myosins – roles for molecular transporters and anchors

Myosin motors on the pathway of viral infections

Viruses and phospholipids: Friends and foes during infection

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