Nuclear nonmetastatic protein 23‐H1 expression and epithelial‐mesenchymal transition in laryngeal carcinoma: A pilot investigation

Marioni, Gino; Cappellesso, Rocco; Ottaviano, Giancarlo; Fasanaro, Elena; Marchese‐Ragona, Rosario; Favaretto, Niccolò; Giacomelli, Luciano; Guzzardo, Vincenza; Fassina, Ambrogio; Blandamura, Stella

doi:10.1002/hed.25188

Cited by 4 publications

(2 citation statements)

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“…19 The EMT program was recently investigated in LSCC too. 20 In 2015, Cappellesso et al 12 analyzed the clinical and pathological role of E-cadherin, N-cadherin, Snail, Slug, Zeb1, and Zeb2 in 37 consecutive cases of LSCC. Low E-cadherin levels and high Slug levels correlated with both a higher disease recurrence rate and a shorter disease-free survival.…”

Section: Discussionmentioning

confidence: 99%

β-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinoma

et al. 2019

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Aim: The novel primary end-point of the present study was to ascertain β-arrestin-1 expression in a cohort of consecutive patients with laryngeal squamous cell carcinoma (LSCC) with information available on their cigarette-smoking habits. A secondary end-point was to conduct a preliminary clinical and pathological investigation into the possible role of β-arrestin-1 in the epithelial-to-mesenchymal transition (EMT), identified by testing for E-cadherin, Zeb1, and Zeb2 expression, in the setting of LSCC. Methods: The expression of β-arrestin-1, E-cadherin, zeb1, and zeb2 was ascertained in 20 consecutive LSCCs. Results: Statistical analysis showed no significant associations between β-arrestin-1 and EMT (based on the expression of E-cadherin, Zeb1, and Zeb2). The combined effect of nicotine and β-arrestin-1 was significantly associated with a shorter disease-free survival ( P=0.01) in our series of LSCC. This latter result was also confirmed in an independent, publicly available LSCC cohort ( P=0.047). Conclusions: Further investigations on larger series (ideally in prospective settings) are needed before we can consider closer follow-up protocols and/or more aggressive treatments for patients with LSCC and a combination of nicotine exposure and β-arrestin-1 positivity in tumor cells at the time of their diagnosis. Further studies on how β-arrestin functions in cancer via different signaling pathways might reveal potential targets for the treatment of even advanced laryngeal malignancies.

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Section: Discussionmentioning

confidence: 99%

β-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinoma

et al. 2019

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“…Similar to IPI score, these prognostic models also did not include tumor-specific biological factors, and can therefore not be used for targeted therapies (31,34). nm23, TOP2A, MUM-1 and VEGF are very common markers used to estimate the progression, infiltration and metastasis ability of many malignant tumors, particularly carcinomas (14,(40)(41)(42)(43)(44). Although their prognostic role in various carcinomas has been widely investigated over time, such as breast (45), pancreatic (12) and renal cell carcinoma (42), to the best of our knowledge, a limited number of have focused on their value in lymphomas.…”

Section: Discussionmentioning

confidence: 99%

nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T‑cell lymphoma, not otherwise specified

et al. 2019

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Nuclear expression of onco-suppressors nm23-H1 and maspin are associated with lower recurrence rate in laryngeal carcinoma

Marioni

Ottaviano

Filippis

et al. 2019

American Journal of Otolaryngology

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Nuclear nonmetastatic protein 23‐H1 expression and epithelial‐mesenchymal transition in laryngeal carcinoma: A pilot investigation

Abstract: Nuclear nm23-H1 expression warrants further investigation in laryngeal SCC as a prognostic marker identifying patients at higher risk of recurrence. nm23-H1 targeted treatments may be capable of regulating epithelial-to-mesenchymal transition.

Cited by 4 publications

References 35 publications

β-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinoma

β-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinoma

nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T‑cell lymphoma, not otherwise specified

Nuclear expression of onco-suppressors nm23-H1 and maspin are associated with lower recurrence rate in laryngeal carcinoma

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